Human Anti-ITGA2B Recombinant Antibody (PABL-747)
CAT#: PABL-747
Recombinant Human Antibody is capable of binding to ITGA2B, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ITGA2B mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ITGA2B proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody inhibits ligand binding by a mechanism different from that of all other α(IIb)β(3) antagonists and may offer advantages as a therapeutic agent.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31169/1877_G7_33_selected.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31168/73889_B_5_4.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (HEL, HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005961-ITGA2B
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Specifications
- Immunogen
- Human integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG
- Specificity
- Human ITGA2B
- Species Reactivity
- Human
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93; integrin alpha-IIb; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit; protein phosphatase 1, regulatory subunit 93
- Gene ID
- 3674
- UniProt ID
- P08514
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| HPAB-0277-YC-F(E) | Human Anti-ITGA2B Recombinant Antibody; Fab Fragment (HPAB-0277-YC-F(E)) | FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
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| HPAB-0276-YC-S(P) | Mouse Anti-ITGA2B Recombinant Antibody; scFv Fragment (HPAB-0276-YC-S(P)) | FuncS | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0056MZ | Recombinant Mouse Anti-Human CD41 Antibody (clone TZ.23) | WB, IP, FC | Mouse antibody |
| HPAB-0275-YC | Mouse Anti-ITGA2B Recombinant Antibody (HPAB-0275-YC) | ELISA, FuncS | Mouse IgG |
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| CAT | Product Name | Application | Type |
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| NEUT-1546CQ | Recombinant Mouse Anti-ITGA2B Antibody (HIP8) | CyTOF, FuncS, FC, IFC, IHC, Neut | IgG1, κ |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-1124-YJ7 | Human Anti-ITGA2B Recombinant Autoantibody (clone 2E7) | ELISA, FuncS | Human IgM |
| CAT | Product Name | Application | Type |
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| VS-0425-FY85 | Human Anti-ITGA2B scFv-Fc Chimera (VS-0425-FY85) | FC, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC591 | Recombinant Anti-ITGA2B Vesicular Antibody, EV Displayed (VS-0425-YC591) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY3618 | Anti-ITGA2B Immunohistochemistry Kit | IHC | |
| VS-0525-XY3619 | Anti-Mouse ITGA2B Immunohistochemistry Kit | IHC |
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