Anti-Human CD41 Recombinant Antibody Fab Fragment (Abciximab) (CAT#: TAB-015-F(E))

Recombinant monoclonal antibody Fragment Fab to Human CD41. Abciximab (previously known as c7E3 Fab), a glycoprotein IIb/IIIa receptor antagonist, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. It is a glycoprotein IIb/IIIa inhibitor.
While abciximab has a short plasma half-life, due to its strong affinity for its receptor on the platelets, it may occupy some receptors for weeks. In practice, platelet aggregation gradually returns to normal about 96 to 120 hours after discontinuation of the drug. E27-E35 Abciximab is made from the Fab Fragment of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet membrane.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • Fab - G1 - kappa
  • Specificity
  • Tested positive against native human antigen
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.
  • Trade name
  • reopro
  • CAS
  • 143653-53-6
  • Generic Name
  • Abciximab
  • Biological Half-Life
  • <10 min–30 min
  • ATC Code
  • B01AC13
  • DrugBank
  • DB00054
  • UNII
  • X85G7936GV
  • ChEMBL
  • CHEMBL1201584
  • MW
  • 47455.4 g/mol
  • Related Disease
  • Refractory unstable angina when percutaneous coronary intervention is planned

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • Abciximab;reopro;143653-53-6;c7E3 Fab;c7E3 Fab;glycoprotein IIb/IIIa inhibitor;DB00054ITGA2B;integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41);GP2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen

Related Resources

  • Biosimilar Overview
Please refer to Abciximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Abciximab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ITGA2B"

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1546CQ Recombinant Mouse Anti-ITGA2B Antibody (HIP8) CyTOF, FuncS, FC, IFC, IHC, Neut IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-1547CQ Recombinant Mouse Anti-ITGA2B Antibody (PAC1) FC, IP, WB, BL IgM, κ
NEUT-1548CQ Recombinant Mouse Anti-ITGA2B Antibody (A2A9/6) FC, BL, IP IgG2a, κ

Rabbit Monoclonal Antibody

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0578CQ Recombinant Mouse Anti-Human ITGA2B Antibody (1E6) ELISA IgG2a

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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