Anti-Human CD41 Recombinant Antibody Fab Fragment (Abciximab) (CAT#: TAB-015-F(E))
Recombinant monoclonal antibody Fragment Fab to Human CD41. Abciximab (previously known as c7E3 Fab), a glycoprotein IIb/IIIa receptor antagonist, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. It is a glycoprotein IIb/IIIa inhibitor.
While abciximab has a short plasma half-life, due to its strong affinity for its receptor on the platelets, it may occupy some receptors for weeks. In practice, platelet aggregation gradually returns to normal about 96 to 120 hours after discontinuation of the drug. E27-E35 Abciximab is made from the Fab Fragment of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet membrane.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31169/1877_G7_33_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31169/1877_G7_33_selected.jpg
Figure 2 Bone marrow
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31168/73889_B_5_4.jpg
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31168/73889_B_5_4.jpg
Figure 3 RNA cell line category: Group enriched (HEL, HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005961-ITGA2B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005961-ITGA2B
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Chimeric (mouse/human)
- Type
- Fab - G1 - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.
- Trade name
- reopro
- CAS
- 143653-53-6
- Generic Name
- Abciximab
- Biological Half-Life
- <10 min–30 min
- ATC Code
- B01AC13
- DrugBank
- DB00054
- UNII
- X85G7936GV
- ChEMBL
- CHEMBL1201584
- MW
- 47455.4 g/mol
- Related Disease
- Refractory unstable angina when percutaneous coronary intervention is planned
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- Abciximab;reopro;143653-53-6;c7E3 Fab;c7E3 Fab;glycoprotein IIb/IIIa inhibitor;DB00054ITGA2B;integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41);GP2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen
- Gene ID
- 3674
- UniProt ID
- P08514
Related Resources
Please refer to Abciximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Abciximab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-740 | Human Anti-ITGA2B Recombinant Antibody (clone RUC-2); Fab Fragment | Block | Human Fab |
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| HPAB-0276-YC-F(E) | Mouse Anti-ITGA2B Recombinant Antibody; Fab Fragment (HPAB-0276-YC-F(E)) | FuncS | Mouse Fab |
| HPAB-0277-YC-F(E) | Human Anti-ITGA2B Recombinant Antibody; Fab Fragment (HPAB-0277-YC-F(E)) | FuncS | Humanized Fab |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-015-F(E), RRID: AB_3111747)
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