Human Anti-ITGA2B scFv-Fc Chimera (VS-0425-FY85)
CAT#: VS-0425-FY85
This fusion protein targets ITGA2B (Integrin alpha-2b), which is involved in platelet aggregation and thrombus formation. It has potential applications in thrombotic disorders and cancer metastasis by modulating cell adhesion processes.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31169/1877_G7_33_selected.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31168/73889_B_5_4.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (HEL, HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005961-ITGA2B
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CD41
- Species Reactivity
- Human
- Applications
- Flow Cytometry, Blocking
- Related Disease
- Glanzmann Thrombasthenia 1 and Bleeding Disorder, Platelet-Type, 16
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 1 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Integrin Subunit Alpha 2b
- Gene ID
- 3674
- UniProt ID
- P08514
- Long Name
- Integrin Subunit Alpha 2b
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Membrane
- Protein Refseq
- NP_000410.2
- Function
- Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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