Afuco™ Anti-Human Integrin α5β1 ADCC Recombinant Antibody (PF-04605412), ADCC Enhanced (CAT#: AFC-425CL)
Anti-Integrin α5β1 ADCC Enhanced Antibody (PF-04605412) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a fully human, fragment crystalizable (Fc)-engineered IgG1 mAb, which specifically neutralizes α5 and binds the Fcγ receptors (FcγR) with enhanced affinity. In vitro, PF-5412 potently inhibited α5β1-mediated intracellular signaling, cell adhesion, migration, and endothelial cell (EC) tubulogenesis. The dual mechanism of action and robust antitumor efficacy of PF-5412 support its clinical development for the treatment of a broad spectrum of human malignancies.
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Figure 1 Median concentrations of PF-04605412 over time for cycle 1 by dose level
Mateo, J., Berlin, J., De Bono, J. S., Cohen, R. B., Keedy, V., Mugundu, G., ... & Borghaei, H. (2014). A first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors. Cancer chemotherapy and pharmacology, 74(5), 1039-1046.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer; Solid Tumors
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- ≤1 year at -20°C.
Target
- Alternative Names
- Integrin α5β1; GPV/IIIa; GPV/IIa
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
Mouse Antibody Products
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ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-719LC-F(E) | Anti-human Integrin α5β1 Fab Fragment (3C2.2A8) | ELISA, FC | Human antibody |
| TAB-720LC-F(E) | Anti-human Integrin α5β1 Fab Fragment (3C5) | ELISA, FC | Human antibody |
| TAB-721LC-F(E) | Anti-human Integrin α5β1 Fab Fragment (5B11) | ELISA, FC | Human antibody |
| TAB-722LC-F(E) | Anti-human Integrin α5β1 Fab Fragment (MOR04055) | ELISA, FC | Human antibody |
| TAB-723LC-F(E) | Anti-human Integrin α5β1 Fab Fragment (MOR04624) | ELISA, FC | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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