Afuco™ Anti-Human Integrin α5β1 ADCC Recombinant Antibody (PF-04605412), ADCC Enhanced
CAT#: AFC-425CL
Anti-Integrin α5β1 ADCC Enhanced Antibody (PF-04605412) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a fully human, fragment crystalizable (Fc)-engineered IgG1 mAb, which specifically neutralizes α5 and binds the Fcγ receptors (FcγR) with enhanced affinity. In vitro, PF-5412 potently inhibited α5β1-mediated intracellular signaling, cell adhesion, migration, and endothelial cell (EC) tubulogenesis. The dual mechanism of action and robust antitumor efficacy of PF-5412 support its clinical development for the treatment of a broad spectrum of human malignancies.
Published Data
Figure 1 Median concentrations of PF-04605412 over time for cycle 1 by dose level
Mateo, J., Berlin, J., De Bono, J. S., Cohen, R. B., Keedy, V., Mugundu, G., ... & Borghaei, H. (2014). A first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors. Cancer chemotherapy and pharmacology, 74(5), 1039-1046.
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer; Solid Tumors
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- ≤1 year at -20°C.
Target
- Alternative Names
- Integrin α5β1; GPV/IIIa; GPV/IIa
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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