Human Anti-KLRK1 Recombinant Antibody (TAB-0002CL) (CAT#: TAB-0002CL)
This product is a recombinant human antibody that recognizes NKG2D. The antibody was purified by affinity chromatography.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
Figure 2 High expression in spleen.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
Figure 3 Low expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
Figure 5 Spleen
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
Figure 6 RNA cell line category: Cell line enriched (U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
Specifications
- Host Species
- Human
- Type
- Human IgG4
- Specificity
- Human
- Species Reactivity
- Human
- Applications
- ELISA, WB, FC, RIA, Block, IA
- Related Disease
- Typically useful for treatment of conditions where NKG2D activity should be reduced. Such antibodies can reduce or inhibit activation of NKG2D-expressing NK and/or T cells by, e.g., competing with or blocking one or more endogenous NKG2D-ligands for binding to NKG2D, down-modulating or otherwise reducing the amount of cell-surface NKG2D upon binding, and/or eliciting an ADCC or CDC response against the cells.
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- KLRK1; killer cell lectin-like receptor subfamily K, member 1; KLR; CD314; NKG2D; NKG2-D; D12S2489E; NKG2-D type II integral membrane protein; NK cell receptor D; NKG2-D-activating NK receptor
- Gene ID
- 22914
- UniProt ID
- A0A024RAP8
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1686z | Mouse Anti-KLRK1 Recombinant Antibody (clone 1H3) | FC, ICC, IF, IHC, IP, FuncS | Mouse IgG1 |
| HPAB-0726-FY | Mouse Anti-KLRK1 Recombinant Antibody (clone AB121) | ELISA | Mouse IgG |
| VS3-FY2752 | Mouse Anti-KLRK1 Recombinant Antibody (VS3-FY2752) | WB, FC, ELISA | Mouse IgG |
| VS11-QX87 | Mouse Anti-KLRK1 Recombinant Antibody (clone 11B2D10) | FC, Block | Mouse IgG1, κ |
| VS11-QX88 | Mouse Anti-KLRK1 Recombinant Antibody (clone 6E5A7) | FC, Block | Mouse IgG2b, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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