Human Anti-KLRK1 (clone KYK-2.0) scFv-Fc Chimera (CAT#: VS-0325-FY18)
The anti-KLRK1 scFv-Fc antibody is a recombinant antibody that is designed to bind to the KLRK1 protein, consisting of a single-chain variable fragment (scFv) linked to the Fc region of an immunoglobulin. The Fc region enhances stability and imparts effector functions to the antibody. These anti-KLRK1 scFv-Fc antibodies are valuable tools in research and can be created using synthetic biology techniques.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
Figure 2 High expression in spleen.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
Figure 3 Low expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
Figure 5 Spleen
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
Figure 6 RNA cell line category: Cell line enriched (U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human KLRK1
- Species Reactivity
- Human
- Clone
- KYK-2.0
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer, autoimmune disease, or infectious disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Killer Cell Lectin Like Receptor K1; Killer Cell Lectin-Like Receptor Subfamily K, Member 1; NKG2-D-Activating NK Receptor; NK Cell Receptor D; D12S2489E; NKG2D; DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence
- Gene ID
- 22914
- UniProt ID
- P26718
- Long Name
- Killer Cell Lectin Like Receptor K1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn131, Asn163, and Asn202
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- NP_031386.2
- Function
- Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation.
Stimulates perforin-mediated elimination of ligand-expressing tumor cells.
Signaling involves calcium influx, culminating in the expression of TNF-alpha.
Participates in NK cell-mediated bone marrow graft rejection.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
Human Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Single Domain Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1686z | Mouse Anti-KLRK1 Recombinant Antibody (clone 1H3) | FC, ICC, IF, IHC, IP, FuncS | Mouse IgG1 |
| HPAB-0327-CN | Human Anti-KLRK1 Recombinant Antibody (HPAB-0327-CN) | ELISA, FC, Block | Human IgG4 |
| VS3-FY2752 | Mouse Anti-KLRK1 Recombinant Antibody (VS3-FY2752) | WB, FC, ELISA | Mouse IgG |
| VS11-QX87 | Mouse Anti-KLRK1 Recombinant Antibody (clone 11B2D10) | FC, Block | Mouse IgG1, κ |
| VS11-QX88 | Mouse Anti-KLRK1 Recombinant Antibody (clone 6E5A7) | FC, Block | Mouse IgG2b, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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