Human Anti-KLRK1 (clone KYK-2.0) scFv-Fc Chimera
CAT#: VS-0325-FY18
The anti-KLRK1 scFv-Fc antibody is a recombinant antibody that is designed to bind to the KLRK1 protein, consisting of a single-chain variable fragment (scFv) linked to the Fc region of an immunoglobulin. The Fc region enhances stability and imparts effector functions to the antibody. These anti-KLRK1 scFv-Fc antibodies are valuable tools in research and can be created using synthetic biology techniques.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
Normal Tissue
Figure 2 High expression in spleen.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
Normal Tissue
Figure 3 Low expression in cerebral cortex.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human KLRK1
- Species Reactivity
- Human
- Clone
- KYK-2.0
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer, autoimmune disease, or infectious disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Killer Cell Lectin Like Receptor K1; Killer Cell Lectin-Like Receptor Subfamily K, Member 1; NKG2-D-Activating NK Receptor; NK Cell Receptor D; D12S2489E; NKG2D; DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence
- Gene ID
- 22914
- UniProt ID
- P26718
- Long Name
- Killer Cell Lectin Like Receptor K1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn131, Asn163, and Asn202
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- NP_031386.2
- Function
- Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation.
Stimulates perforin-mediated elimination of ligand-expressing tumor cells.
Signaling involves calcium influx, culminating in the expression of TNF-alpha.
Participates in NK cell-mediated bone marrow graft rejection.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone KYK-2.0"
- CAT
- Product Name
See other products for "KLRK1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0002CL | Human Anti-KLRK1 Recombinant Antibody (TAB-0002CL) | ELISA, WB, FC, RIA, Block, IA | Human IgG4 |
| TAB-0002CL-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (TAB-0002CL-S(P)) | ELISA, WB, FC, RIA, Block, IA | Human scFv |
| TAB-520MZ | Anti-Human KLRK1 Recombinant Antibody (KYK-1.0) | ELISA | Human antibody |
| TAB-520MZ-F(E) | Anti-Human KLRK1 Recombinant Antibody Fab Fragment (KYK-1.0) | SDS-PAGE, ELISA | Human antibody |
| TAB-521MZ-F(E) | Anti-Human KLRK1 Recombinant Antibody Fab Fragment (KYK-2.0) | SDS-PAGE, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1660CQ | Recombinant Mouse Anti-KLRK1 Antibody (5C6) | FC, FuncS, IHC, IP, Neut | IgG2a |
| NEUT-1661CQ | Recombinant Armenian hamster Anti-Klrk1 Antibody (NEUT-1661CQ) | FC, FuncS, Neut | IgG |
| NEUT-1663CQ | Recombinant Rat Anti-Klrk1 Antibody (MI6) | FC, FuncS, Neut | IgG2a, λ |
| NEUT-1667CQ | Recombinant Mouse Anti-KLRK1 Antibody (CBL019) | FC, WB, Neut | IgG1 |
| NEUT-1668CQ | Recombinant Mouse Anti-KLRK1 Antibody (CBL703) | WB, FC, Costim, CyTOF, Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1662CQ | Recombinant Rat Anti-Klrk1 Antibody (VMC202) | FC, BL | IgG1, κ |
| NEUT-1664CQ | Recombinant Hamster Anti-Klrk1 Antibody (VMC203) | BL | IgG |
| NEUT-1665CQ | Recombinant Hamster Anti-Klrk1 Antibody (MAB0840) | BL, FC | IgG2 |
| NEUT-1666CQ | Recombinant Rat Anti-Klrk1 Antibody (CBL347) | BL, CyTOF, FC, WB | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0620-CN | Llama Anti-KLRK1 Recombinant Antibody (HPAB-0620-CN) | ELISA, FC | Llama VHH |
| HPAB-0621-CN | Llama Anti-KLRK1 Recombinant Antibody (HPAB-0621-CN) | ELISA, FC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0327-CN-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (HPAB-0327-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0328-CN-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (HPAB-0328-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0329-CN-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (HPAB-0329-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0726-FY-F(E) | Mouse Anti-KLRK1 Recombinant Antibody (clone AB121); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0505-WJ-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (HPAB-0505-WJ-S(P)) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0327-CN-F(E) | Human Anti-KLRK1 Recombinant Antibody; Fab Fragment (HPAB-0327-CN-F(E)) | ELISA, FC, Block | Human Fab |
| HPAB-0328-CN-F(E) | Human Anti-KLRK1 Recombinant Antibody; Fab Fragment (HPAB-0328-CN-F(E)) | ELISA, FC, Block | Human Fab |
| HPAB-0329-CN-F(E) | Human Anti-KLRK1 Recombinant Antibody; Fab Fragment (HPAB-0329-CN-F(E)) | ELISA, FC, Block | Human Fab |
| HPAB-0726-FY-S(P) | Mouse Anti-KLRK1 Recombinant Antibody (clone AB121); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0505-WJ-F(E) | Human Anti-KLRK1 Recombinant Antibody; Fab Fragment (HPAB-0505-WJ-F(E)) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-159CQ | Recombinant Mouse Anti-KLRK1 Antibody (1D11) | FC, FuncS, Neut, IHC | Mouse IgG1, κ |
| FN-178CQ | Recombinant Armenian hamster Anti-KLRK1 Antibody (A10) | FC, FuncS | Armenian hamster IgG |
| FN-237CQ | Recombinant Rat Anti-KLRK1 Antibody (VMC216) | FC, FuncS, Neut | Rat IgG2a, κ |
| VS3-FY2752 | Mouse Anti-KLRK1 Recombinant Antibody (VS3-FY2752) | WB, FC, ELISA | Mouse IgG |
| VS11-QX87 | Mouse Anti-KLRK1 Recombinant Antibody (clone 11B2D10) | FC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC127 | Recombinant Anti-KLRK1 Vesicular Antibody, EV Displayed (VS-0425-YC127) | Cyt, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3816 | Anti-KLRK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3817 | Anti-Rat KLRK1 Immunohistochemistry Kit | IHC |
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