Recombinant Anti-KLRK1 Vesicular Antibody, EV Displayed (VS-0425-YC127)
CAT#: VS-0425-YC127
The Recombinant Anti-KLRK1 Vesicular Antibody, EV Displayed (VS-0425-YC127) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to KLRK1-expressed cells or tissues. The KLRK1 is a protein involved in mediating the lysis of certain tumor and virus-infected cells. It is expressed in natural killer cells and involves interactions with a diverse family of ligands, leading to the activation of NK and T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
Normal Tissue
Figure 2 High expression in spleen.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
Normal Tissue
Figure 3 Low expression in cerebral cortex.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
❮
❯
Recombinant Antibody
- Application
- Cyt, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- KLRK1
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Killer cell lectin like receptor K1
- Biological Process
- Adaptive immunity, Differentiation, Immunity, Innate immunity
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
- Alternative Names
- CD314, D12S2489E, KLR, NKG2-D, NKG2D
- Gene ID
- 22914
- UniProt ID
- P26718
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0328-CN-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (HPAB-0328-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0329-CN-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (HPAB-0329-CN-S(P)) | ELISA, FC, Block | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0327-CN-F(E) | Human Anti-KLRK1 Recombinant Antibody; Fab Fragment (HPAB-0327-CN-F(E)) | ELISA, FC, Block | Human Fab |
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| HPAB-0329-CN-F(E) | Human Anti-KLRK1 Recombinant Antibody; Fab Fragment (HPAB-0329-CN-F(E)) | ELISA, FC, Block | Human Fab |
| HPAB-0726-FY-S(P) | Mouse Anti-KLRK1 Recombinant Antibody (clone AB121); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0505-WJ-F(E) | Human Anti-KLRK1 Recombinant Antibody; Fab Fragment (HPAB-0505-WJ-F(E)) | ELISA, WB | Human Fab |
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