Afuco™ Anti-Human LY75 ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-487CL)
Anti-LY75 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The monoclonal antibodies which bind to human DEC-205 can be used in a variety of dendritic cell-targeted therapies, for example, to enhance antigen presentation and/or induce T cell responses, such as cytotoxic T cell (CTL) responses, against a variety of target cells or pathogens, or to treat antigen presenting cell (APC)-mediated diseases.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
Figure 3 IHC staining of human spleen
(High expression. RNA expression: 18.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
(High expression. RNA expression: 18.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
Figure 4 IHC staining of human skeletal muscle
(Low expression. RNA expression: 0.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
(Low expression. RNA expression: 0.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
Figure 5 Cerebral cortex
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
Figure 6 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
Figure 7 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
Figure 8 Testis
(Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
(Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
Figure 9 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RT4, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- APC-mediated Diseases
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- LY75; lymphocyte antigen 75; CD205; LY-75; CLEC13B; DEC-205; GP200-MR6; C-type lectin domain family 13 member B
- Gene ID
- 4065
- UniProt ID
- O60449
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "LY75"
Select a product category from the dropdown menu below to view related products.
Please select product type
Fab Antibody Products
ScFv Antibody Products
Rabbit Monoclonal Antibody Products
IgG Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-637-F(E) | Recombinant Anti-human LY75 Antibody Fab Fragment | Neut, WB, FuncS | Fab |
| HPAB-0432LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0432LY-F(E)) | ELISA | Human Fab |
| HPAB-0433LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0433LY-F(E)) | ELISA | Human Fab |
| HPAB-0470-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0470-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| HPAB-0471-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0471-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AFC-487CL. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: FC, IB, Block, Inhib, FuncS, ELISA, FACS, IP, IF
Application: ELISA, FuncS, IHC, IF, FC, ADCC
Application: WB, ELISA, IF
Application: ELISA, FC, Inhib
Application: FC, IHC, Cyt, FuncS
Application: ELISA, Neut, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
