Anti-MHC class II Antibody-Cytokine Fusion Protein, IgG (chCLL-1)-GM-CSF (CAT#: ACFP-SH024)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-MHC class II IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. This antibody-cytokine fusion protein retains GM-CSF bioactivity, evaluated by its ability to induce the formation of hematopoietic progenitor colonies from bone marrow mononuclear cells, and also retains the ability to bind the antigens on the surface of cancer cells that express MHC class II. It also demonstrated ADCC in vitro, using human mononuclear cells as effectors. This immunocytokine was designed for treating B-cell NHL and chronic lymphocytic leukemia.
Specific Inquiry
Specifications
- Target
- MHC class II
- Molecule Class
- IgG1-GM-CSF
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- chCLL-1
- Related Disease
- B-cell NHL and chronic lymphocytic leukemia
- Cytokine 1
- GM-CSF
- Cytokines 1 Description
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- DPB1; HLA DP1B; HLA-DPB1; Major histocompatibility complex class II DP beta 1; MHC class II antigen; MHC DPB1; MHC class II; I-Ek
Related Resources
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Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-661 | Recombinant Anti-MHC class II Antibody | ELISA, WB, FuncS | IgG |
| MHH-661 | Recombinant Human Anti-MHC class II Antibody | WB, IF, FuncS | IgG |
| FN-112CQ | Recombinant Mouse Anti-MHC class II Antibody (Y-3) | FC, FuncS | Mouse IgG2b, κ |
| VS3-WK223 | Rabbit Anti-MHC Class II Recombinant Antibody (clone JA10-94) | WB, IP, ICC, IF, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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