Anti-MHC class II Antibody-Cytokine Fusion Protein, IgG (chCLL-1)-GM-CSF
CAT#: ACFP-SH024
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-MHC class II IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. This antibody-cytokine fusion protein retains GM-CSF bioactivity, evaluated by its ability to induce the formation of hematopoietic progenitor colonies from bone marrow mononuclear cells, and also retains the ability to bind the antigens on the surface of cancer cells that express MHC class II. It also demonstrated ADCC in vitro, using human mononuclear cells as effectors. This immunocytokine was designed for treating B-cell NHL and chronic lymphocytic leukemia.
Specifications
- Target
- MHC class II
- Molecule Class
- IgG1-GM-CSF
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- chCLL-1
- Related Disease
- B-cell NHL and chronic lymphocytic leukemia
- Cytokine 1
- GM-CSF
- Cytokines 1 Description
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- DPB1; HLA DP1B; HLA-DPB1; Major histocompatibility complex class II DP beta 1; MHC class II antigen; MHC DPB1; MHC class II; I-Ek
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Related Diseases
Asthma
Rheumatoid Arthritis
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COA
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