Recombinant Human Anti-PfRh5 Antibody (QA1) (CAT#: PABL-691)
Recombinant Human Antibody (QA1) is capable of binding to PfRh5, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-PfRh5 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-PfRh5 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 Investigation of the interaction of PfRH5DNL with a panel of mouse monoclonal antibodies using ELISA.
Five monoclonal antibodies that bind to PfRH5 were coated on an ELISA plate and probed using PfRH5DNL at concentrations of 12.5, 50, 200 or 800 ng ml21. Antibodies 9AD4, QA1 and QA5 interacted with PfRH5DNL while RB3 and 4BA7 did not. Indeed, RB3 and 4BA7 bind to the flexible N terminus and the truncated loop, respectively, both features lacking in PfRH5DNL5. The error bars are standard error of mean (n 5 3).
Wright, K. E., Hjerrild, K. A., Bartlett, J., Douglas, A. D., Jin, J., Brown, R. E., ... & Draper, S. J. (2014). Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature, 515(7527), 427.
Specifications
- Immunogen
- P. falciparum reticulocyte-binding protein homologue 5
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native PfRh5
- Species Reactivity
- P. falciparum
- Clone
- QA1
- Applications
- WB, IHC, IF, FuncS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The PfRh5 antibody has been reported in applications of ELISA.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-302 | Recombinant Mouse Anti-PfRH5 Antibody (QA1) | WB, BL, FuncS | IgG |
| PABL-679 | Mouse Anti-PfRH5 Recombinant Antibody (PABL-679) | ELISA | Mouse IgG |
| PABJ-0163 | Human Anti-PfRH5 Recombinant Antibody (clone R5.011) | ELISA, DB, Synergistic effect | Human IgG |
| PABJ-0164 | Human Anti-PfRH5 Recombinant Antibody (clone R5.016) | ELISA, DB | Human IgG |
| PABJ-0173 | Human Anti-PfRH5 Recombinant Antibody (clone R5.004) | ELISA, DB, Neut | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-302 | Recombinant Mouse Anti-PfRH5 Antibody Fab Fragment (QA1) | WB, BL, FuncS | Fab |
| PFBL-673 | Mouse Anti-PfRH5 Recombinant Antibody; Fab Fragment (PFBL-673) | ELISA | Mouse Fab |
| PFBL-684 | Recombinant Human Anti-PfRh5 Antibody Fab Fragment (QA1) | WB, IHC, IF, FuncS | Fab |
| PABJ-0163-F(E) | Human Anti-PfRH5 Recombinant Antibody (clone R5.011); Fab Fragment | ELISA, DB, Synergistic effect | Human Fab |
| PABJ-0164-F(E) | Human Anti-PfRH5 Recombinant Antibody (clone R5.016); Fab Fragment | ELISA, DB | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-673 | Mouse Anti-PfRH5 Recombinant Antibody; scFv Fragment (PSBL-673) | ELISA | Mouse scFv |
| PSBL-684 | Recombinant Human Anti-PfRh5 Antibody scFv Fragment (QA1) | WB, IHC, IF, FuncS | scFv |
| PABJ-0163-S(P) | Human Anti-PfRH5 Recombinant Antibody (clone R5.011); scFv Fragment | ELISA, DB, Synergistic effect | Human scFv |
| PABJ-0164-S(P) | Human Anti-PfRH5 Recombinant Antibody (clone R5.016); scFv Fragment | ELISA, DB | Human scFv |
| PABJ-0173-S(P) | Human Anti-PfRH5 Recombinant Antibody (clone R5.004); scFv Fragment | ELISA, DB, Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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