Recombinant Anti-human TGM2 Intrabody [(D-Arg)9]
CAT#: IAB-B010(A)
Recombinant anti-TGM2 intrabody linked to (D-Arg)9 works within cells and directes to antigen human TGM2, expressed in CHO cells. The intracellular antibody can inhibit the ransglutaminase activity may be by one or more techniques, including, but not limited to, downregulating transglutaminase expression, inhibiting TG2 translation, or blocking TG2 enzymatic activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/635_D8_3_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/639_D8_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/62634_A_9_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198959-TGM2
❮
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Specifications
- Immunogen
- human transglutaminase 2
- Host Species
- mouse
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Enzyme-linked Immunosorbent Assay; Neutralization; Functional studies
Product Property
- Purity
- >95% by HPLC
- Storage
- ≤1 year at -20°C.
Target
- Alternative Names
- TGM2; transglutaminase 2; TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h; protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; epididymis secret
- Gene ID
- 7052
- UniProt ID
- P21980
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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|---|---|---|---|
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|---|---|---|---|
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| HPAB-AP810-YC-F(E) | Mouse Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP810-YC-F(E)) | ELISA, Inhib | Mouse Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-728 | Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06); scFv Fragment | ELISA | Human scFv |
| HPAB-0313CQ-S(P) | Human Anti-TGM2 Recombinant Antibody (clone 2/A2); scFv Fragment | ELISA, IF | Human scFv |
| HPAB-AP806-YC-S(P) | Human Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP806-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-AP807-YC-S(P) | Human Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP807-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-AP808-YC-S(P) | Mouse Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP808-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-629CT | Human Anti-TGM2 Recombinant Antibody (TAB-629CT) | ELISA, WB, FC | Human antibody |
| TAB-630CT | Human Anti-TGM2 Recombinant Antibody (TAB-630CT) | ELISA, WB, FC | Human antibody |
| TAB-631CT | Human Anti-TGM2 Recombinant Antibody (TAB-631CT) | ELISA, WB, FC | Human antibody |
| TAB-629CT-F(E) | Human Anti-TGM2 Recombinant Antibody; Fab Fragment (TAB-629CT-F(E)) | ELISA, WB, FC | Human Fab |
| TAB-630CT-F(E) | Human Anti-TGM2 Recombinant Antibody; Fab Fragment (TAB-630CT-F(E)) | ELISA, WB, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3555 | Rabbit Anti-TGM2 Recombinant Antibody (clone DS3555AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0081LC | Mouse Anti-TGM2 Recombinant Antibody (clone 40) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP806-YC | Human Anti-TGM2 Recombinant Antibody (HPAB-AP806-YC) | ELISA, Inhib | Humanized IgG |
| HPAB-AP807-YC | Human Anti-TGM2 Recombinant Antibody (HPAB-AP807-YC) | ELISA, Inhib | Humanized IgG |
| HPAB-AP808-YC | Mouse Anti-TGM2 Recombinant Antibody (HPAB-AP808-YC) | ELISA, Inhib | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY512 | Mouse Anti-NHP TGM2 Recombinant Antibody (clone SPM358) | WB, IHC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY76 | Human Anti-TGM2 (clone 679-14-E06) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2279 | Anti-TGM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7221 | Anti-Mouse TGM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7220 | Anti-Human TGM2 Immunohistochemistry Kit | IHC |
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