Human Anti-TGM2 (clone 679-14-E06) scFv-Fc Chimera
CAT#: VS-0125-FY76
Anti-TGM2 scFv-Fc is a recombinant fusion protein designed to target and bind to Transglutaminase 2 (TGM2), an enzyme that plays a crucial role in various biological processes including cell signaling, adhesion, and the formation of extracellular matrix. TGM2 is implicated in several pathological conditions, including celiac disease, neurodegeneration, and various cancers. The scFv-Fc format combines a single-chain variable fragment (scFv) of an antibody with the Fc region of an IgG, enhancing its stability and half-life in circulation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/635_D8_3_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/639_D8_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/62634_A_9_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198959-TGM2
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 679-14-E06
- Applications
- ELISA, Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-TGM2 scFv-Fc specifically binds to TGM2, potentially inhibiting its activity and facilitating research on its role in diseases. By interacting with TGM2, the antibody may counteract pathological processes associated with increased or abnormal TGM2 activity. It can also modulate immune responses, thereby influencing the progression of autoimmune diseases. Due to its specificity, anti-TGM2 scFv-Fc holds promise for development as a therapeutic option, particularly in TGM2-related diseases. This targeted approach could lead to innovative treatments that address the underlying mechanisms involved. Overall, the functionality of anti-TGM2 scFv-Fc underscores its potential significance in both research and clinical applications.
Target
- Alternative Names
- Transglutaminase 2; C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase; Tissue Transglutaminase; Transglutaminase C; Transglutaminase H; EC 2.3.2.13; TGase C; TGase H
- Gene ID
- 7052
- UniProt ID
- P21980
- Sequence Similarities
- Belongs to the transglutaminase superfamily.
- Cellular Localization
- Cytoplasm, cytosol
Nucleus
Chromosome
Secreted, extracellular space, extracellular matrix
Cell membrane
Mitochondrion
- Post Translation Modifications
- Disulfide bond formation inactivates the calcium-dependent acyltransferase activity.
Auto-transglutaminated: Forms covalent cross-links mediated by transglutaminase between Gln-633 and the epsilon-amino group of a lysine residue of itself or HMGB1, forming homopolymers and heteropolymers, respectively.
S-nitrosylated, leading to inactivation of the acyltransferase activity.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011527330.1; XP_047296399.1; XP_054179933.1; XP_054179934.1; XP_054179935.1
- Function
- Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54.
Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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- CAT
- Product Name
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