Human Anti-TGM2 (clone 679-14-E06) scFv-Fc Chimera (CAT#: VS-0125-FY76)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• 679-14-E06

• Applications
• ELISA, Inhibition

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The anti-TGM2 scFv-Fc specifically binds to TGM2, potentially inhibiting its activity and facilitating research on its role in diseases. By interacting with TGM2, the antibody may counteract pathological processes associated with increased or abnormal TGM2 activity. It can also modulate immune responses, thereby influencing the progression of autoimmune diseases. Due to its specificity, anti-TGM2 scFv-Fc holds promise for development as a therapeutic option, particularly in TGM2-related diseases. This targeted approach could lead to innovative treatments that address the underlying mechanisms involved. Overall, the functionality of anti-TGM2 scFv-Fc underscores its potential significance in both research and clinical applications.

• Alternative Names
• Transglutaminase 2; C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase; Tissue Transglutaminase; Transglutaminase C; Transglutaminase H; EC 2.3.2.13; TGase C; TGase H

• Gene ID
• 7052

• UniProt ID
• P21980

• Sequence Similarities
• Belongs to the transglutaminase superfamily.

• Cellular Localization
• Cytoplasm, cytosol
  Nucleus
  Chromosome
  Secreted, extracellular space, extracellular matrix
  Cell membrane
  Mitochondrion

• Post Translation Modifications
• Disulfide bond formation inactivates the calcium-dependent acyltransferase activity.
  Auto-transglutaminated: Forms covalent cross-links mediated by transglutaminase between Gln-633 and the epsilon-amino group of a lysine residue of itself or HMGB1, forming homopolymers and heteropolymers, respectively.
  S-nitrosylated, leading to inactivation of the acyltransferase activity.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt
  Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_011527330.1; XP_047296399.1; XP_054179933.1; XP_054179934.1; XP_054179935.1

• Function
• Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54.
  Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• PABL-735
• Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06)

• PFBL-728
• Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06); Fab Fragment

• PSBL-728
• Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06); scFv Fragment

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