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Recombinant Anti-human TGM2 Intrabody [Tat] (CAT#: IAB-B010(T))

Recombinant anti-TGM2 intrabody in fusion with HIV Tat works within cells and directes to antigen human TGM2, expressed in CHO cells. The intracellular antibody can inhibit the ransglutaminase activity may be by one or more techniques, including, but not limited to, downregulating transglutaminase expression, inhibiting TG2 translation, or blocking TG2 enzymatic activity.


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Specific Inquiry
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  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/635_D8_3_selected.jpg
Figure 3 IF staining of human cell line A-431
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/639_D8_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Figure 4 Colon
(Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/62634_A_9_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000198959-TGM2
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198959-TGM2

Specifications

  • Immunogen
  • human transglutaminase 2
  • Host Species
  • mouse
  • Type
  • scFv-Tat
  • Cell Penetrating Peptide
  • TAT
    TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
  • Species Reactivity
  • human
  • Applications
  • Used for immunoassay techniques such as: Fluorescence-activated cell sorting; Enzyme-linked Immunosorbent Assay; Immunofluorescence; Functional studies

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.

Target

  • Alternative Names
  • TGM2; transglutaminase 2; TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h; protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; epididymis secret

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "TGM2"

Intrabody

CAT Product Name Application Type
IAB-B010(A) Recombinant Anti-human TGM2 Intrabody [(D-Arg)9] ELISA, Neut, FuncS scFv-(D-Arg)9
IAB-B010(G) Recombinant Anti-human TGM2 Intrabody [+36 GFP] PCA, WB, FuncS scFv-(+36GFP)

Recombinant Antibody

CAT Product Name Application Type
PABL-735 Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06) ELISA Human IgG
HPAB-AP806-YC Human Anti-TGM2 Recombinant Antibody (HPAB-AP806-YC) ELISA, Inhib Humanized IgG
HPAB-AP807-YC Human Anti-TGM2 Recombinant Antibody (HPAB-AP807-YC) ELISA, Inhib Humanized IgG
HPAB-AP808-YC Mouse Anti-TGM2 Recombinant Antibody (HPAB-AP808-YC) ELISA, Inhib Mouse IgG
HPAB-AP809-YC Mouse Anti-TGM2 Recombinant Antibody (HPAB-AP809-YC) ELISA, Inhib Mouse IgG

Fab Fragment Antibody

CAT Product Name Application Type
PFBL-728 Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06); Fab Fragment ELISA Human Fab
HPAB-AP806-YC-F(E) Human Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP806-YC-F(E)) ELISA, Inhib Humanized Fab
HPAB-AP807-YC-F(E) Human Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP807-YC-F(E)) ELISA, Inhib Humanized Fab
HPAB-AP808-YC-F(E) Mouse Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP808-YC-F(E)) ELISA, Inhib Mouse Fab
HPAB-AP809-YC-F(E) Mouse Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP809-YC-F(E)) ELISA, Inhib Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
PSBL-728 Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06); scFv Fragment ELISA Human scFv
HPAB-AP806-YC-S(P) Human Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP806-YC-S(P)) ELISA, Inhib Human scFv
HPAB-AP807-YC-S(P) Human Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP807-YC-S(P)) ELISA, Inhib Human scFv
HPAB-AP808-YC-S(P) Mouse Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP808-YC-S(P)) ELISA, Inhib Mouse scFv
HPAB-AP809-YC-S(P) Mouse Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP809-YC-S(P)) ELISA, Inhib Mouse scFv

Human Antibody

CAT Product Name Application Type
TAB-629CT-S(P) Human Anti-TGM2 Recombinant Antibody; scFv Fragment (TAB-629CT-S(P)) ELISA, WB, FC Human scFv
TAB-630CT-S(P) Human Anti-TGM2 Recombinant Antibody; scFv Fragment (TAB-630CT-S(P)) ELISA, WB, FC Human scFv
TAB-631CT-S(P) Human Anti-TGM2 Recombinant Antibody; scFv Fragment (TAB-631CT-S(P)) ELISA, WB, FC Human scFv
TAB-629CT-F(E) Human Anti-TGM2 Recombinant Antibody; Fab Fragment (TAB-629CT-F(E)) ELISA, WB, FC Human Fab
TAB-630CT-F(E) Human Anti-TGM2 Recombinant Antibody; Fab Fragment (TAB-630CT-F(E)) ELISA, WB, FC Human Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3555 Rabbit Anti-TGM2 Recombinant Antibody (clone DS3555AB) IHC-P, IP, WB Rabbit IgG

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0081LC Mouse Anti-TGM2 Recombinant Antibody (clone 40) ELISA Mouse IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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