Recombinant Anti-human TGM2 Intrabody [Tat]
CAT#: IAB-B010(T)
Recombinant anti-TGM2 intrabody in fusion with HIV Tat works within cells and directes to antigen human TGM2, expressed in CHO cells. The intracellular antibody can inhibit the ransglutaminase activity may be by one or more techniques, including, but not limited to, downregulating transglutaminase expression, inhibiting TG2 translation, or blocking TG2 enzymatic activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/635_D8_3_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2598/639_D8_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29518/62634_A_9_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 5 RNA cell line category: Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198959-TGM2
❮
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Specifications
- Immunogen
- human transglutaminase 2
- Host Species
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Fluorescence-activated cell sorting; Enzyme-linked Immunosorbent Assay; Immunofluorescence; Functional studies
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.
Target
- Alternative Names
- TGM2; transglutaminase 2; TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h; protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; epididymis secret
- Gene ID
- 7052
- UniProt ID
- P21980
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1191z | Mouse Anti-TGM2 Recombinant Antibody (clone 20C5) | FC, ICC, IF, IHC | Mouse IgG2a, κ |
| PABL-735 | Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06) | ELISA | Human IgG |
| MOB-1819CT | Recombinant Mouse anti-Human TGM2 Monoclonal antibody (2A1) | ELISA, WB | |
| HPAB-0313CQ | Human Anti-TGM2 Recombinant Antibody (clone 2/A2) | Cyt, FuncS, ELISA, Inhib | Human IgG |
| MRO-1525-CN | Rabbit Anti-TGM2 Recombinant Antibody (clone JU30-02) | WB, IHC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B010(A) | Recombinant Anti-human TGM2 Intrabody [(D-Arg)9] | ELISA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B010(G) | Recombinant Anti-human TGM2 Intrabody [+36 GFP] | PCA, WB, FuncS | scFv-(+36GFP) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-728 | Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06); Fab Fragment | ELISA | Human Fab |
| HPAB-AP806-YC-F(E) | Human Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP806-YC-F(E)) | ELISA, Inhib | Humanized Fab |
| HPAB-AP807-YC-F(E) | Human Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP807-YC-F(E)) | ELISA, Inhib | Humanized Fab |
| HPAB-AP808-YC-F(E) | Mouse Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP808-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-AP809-YC-F(E) | Mouse Anti-TGM2 Recombinant Antibody; Fab Fragment (HPAB-AP809-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-728 | Human Anti-TGM2 Recombinant Antibody (clone 679-14-E06); scFv Fragment | ELISA | Human scFv |
| HPAB-0313CQ-S(P) | Human Anti-TGM2 Recombinant Antibody (clone 2/A2); scFv Fragment | ELISA, IF | Human scFv |
| HPAB-AP806-YC-S(P) | Human Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP806-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-AP807-YC-S(P) | Human Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP807-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-AP808-YC-S(P) | Mouse Anti-TGM2 Recombinant Antibody; scFv Fragment (HPAB-AP808-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-629CT | Human Anti-TGM2 Recombinant Antibody (TAB-629CT) | ELISA, WB, FC | Human antibody |
| TAB-630CT | Human Anti-TGM2 Recombinant Antibody (TAB-630CT) | ELISA, WB, FC | Human antibody |
| TAB-629CT-S(P) | Human Anti-TGM2 Recombinant Antibody; scFv Fragment (TAB-629CT-S(P)) | ELISA, WB, FC | Human scFv |
| TAB-630CT-S(P) | Human Anti-TGM2 Recombinant Antibody; scFv Fragment (TAB-630CT-S(P)) | ELISA, WB, FC | Human scFv |
| TAB-631CT-S(P) | Human Anti-TGM2 Recombinant Antibody; scFv Fragment (TAB-631CT-S(P)) | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3555 | Rabbit Anti-TGM2 Recombinant Antibody (clone DS3555AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0081LC | Mouse Anti-TGM2 Recombinant Antibody (clone 40) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1330 | AbPlus™ Anti-TGM2 Magnetic Beads (VS-0724-YC1330) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC96 | Rabbit Anti-TGM2 Antibody (VS-0924-YC96) - Cancer Stem Cell Marker | IHC, WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY512 | Mouse Anti-NHP TGM2 Recombinant Antibody (clone SPM358) | WB, IHC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY76 | Human Anti-TGM2 (clone 679-14-E06) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2279 | Anti-TGM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7221 | Anti-Mouse TGM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7220 | Anti-Human TGM2 Immunohistochemistry Kit | IHC |
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