Afuco™ Anti-Human TNC ADCC Recombinant Antibody (F16-131I), ADCC Enhanced
CAT#: AFC-600CL
Anti-TNC ADCC Enhanced Antibody (F16-131I) is an ADCC enhanced antibody produced by our Afuco™ platform. The monoclonal antibodies F16-131I specific to F16 (specific to the A1 domain of tenascin-C) are currently investigated in Phase I and Phase II clinical trials in patients with cancer and with rheumatoid arthritis.
Published Data
Gene Expression
Figure 9 Immunofluorescence staining of head and neck cancer samples.
The expression patterns and intensities of the splice isoforms extra domain A (EDA) and extradomain B (EDB) of fibronectin and the A1 domain of tenascin C were detected with the antibodies F8, L19 and F16, respectively (shown in green). A co-staining with an anti-von Willebrand factor antibody that stains blood vessels (red) and Dapi (blue) was performed. Abbreviations: SCC: squamous cell carcinoma; PA: pleomorphic adenoma.
Schwager, K., Villa, A., Rösli, C., Neri, D., Rösli-Khabas, M., & Moser, G. (2011). A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer. Head & neck oncology, 3(1), 25.
FuncS
Figure 10 Analysis of staining intensities.
Comparison of staining intensities obtained with the antibodies F8, L19 and F16 in A) primary tumours and metastasis tumour samples and in B) primary benign and primary maligant tumour specimens. C) Average staining intensities of tumours of the oral cavity, the pharynx or the larynx. Standard Errors of the Mean of scoring values are displayed.
Schwager, K., Villa, A., Rösli, C., Neri, D., Rösli-Khabas, M., & Moser, G. (2011). A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer. Head & neck oncology, 3(1), 25.
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Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- IHC, FuncS, IF
- Related Disease
- Hematologic Malignancies; Solid Tumors
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Applications
- Application Notes
- The antibody was validated for Immunohistochemistry, Function Assay, Immunofluorescence. For details, refer to Published Data.
Target
- Alternative Names
- TNC; tenascin C; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225; tenascin; GP 150-225; cytotactin; neuronectin; myotendinous antigen; hexabrachion (tenascin); tenascin-C isoform 14/AD1/16; tenascin-C additional domain 1; deafness, autosomal dominant 56; glioma-associated-extracellular matrix antigen
- Gene ID
- 3371
- UniProt ID
- B4E1W8
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1379z | Mouse Anti-TNC Recombinant Antibody (clone 22B10) | WB, IP, IF, IHC, ELISA | Mouse IgG1 |
| MOB-2007CT | Recombinant Mouse anti-Human TNC Monoclonal antibody (C764N) | IHC-Fr, IHC-P | |
| HPAB-0441-YC | Mouse Anti-TNC Recombinant Antibody (clone ST2146) | ELISA, WB, FC, FuncS | Mouse IgG2b, κ |
| HPAB-N0264-YC | Human Anti-TNC Recombinant Antibody (HPAB-N0264-YC) | ELISA, FuncS | Human IgG |
| HPAB-N0265-YC | Human Anti-TNC Recombinant Antibody (HPAB-N0265-YC) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-877 | Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) | IHC | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-587CT | Human Anti-TNC Recombinant Antibody (TAB-587CT) | ELISA, FC | Human IgG4 |
| TAB-588CT | Human Anti-TNC Recombinant Antibody (TAB-588CT) | ELISA, FC | Human IgG4 |
| TAB-589CT | Human Anti-TNC Recombinant Antibody (TAB-589CT) | ELISA, FC | Human IgG4 |
| TAB-590CT | Human Anti-TNC Recombinant Antibody (TAB-590CT) | ELISA, FC | Human IgG4 |
| TAB-591CT | Anti-Human Tenascin C Recombinant Antibody (2B10) | ELISA, IF | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0810MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| BRD-0910MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2050CQ | Rat Anti-TNC Recombinant Antibody (clone CBL402) | WB, ICC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3601 | Rabbit Anti-TNC Recombinant Antibody (clone DS3601AB) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2108 | PE-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM | |
| MHC-LC2109 | APC-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-F(E) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| HPAB-0443-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0443-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0444-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0444-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0445-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0445-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0190-WJ-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0190-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0678-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-M0678-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0190-WJ-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0190-WJ-S(P)) | ELISA | Human scFv |
| HPAB-AP203-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-AP203-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-AP204-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-AP204-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-N0264-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-N0264-YC-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-877 | Afuco™ Anti-TNC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-877) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0083-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0083-YJ-VHH) | ELISA, IF | Camelid VHH |
| NBD-0084-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0084-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| NBD-0085-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0085-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY187 | Human Anti-TNC (clone F16-131I) scFv-Fc Chimera | IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2312 | Anti-TNC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7346 | Anti-Human TNC Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC313 | Recombinant Anti-TNC Eliminating Antibody, pH-Sensitive (ST2146 var.) | Antigen-Sweeping In Vivo. | Mouse IgG2b kappa |
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