Afuco™ Anti-Human TNC ADCC Recombinant Antibody (F16-131I), ADCC Enhanced (CAT#: AFC-600CL)
Anti-TNC ADCC Enhanced Antibody (F16-131I) is an ADCC enhanced antibody produced by our Afuco™ platform. The monoclonal antibodies F16-131I specific to F16 (specific to the A1 domain of tenascin-C) are currently investigated in Phase I and Phase II clinical trials in patients with cancer and with rheumatoid arthritis.
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Figure 9 Immunofluorescence staining of head and neck cancer samples.
The expression patterns and intensities of the splice isoforms extra domain A (EDA) and extradomain B (EDB) of fibronectin and the A1 domain of tenascin C were detected with the antibodies F8, L19 and F16, respectively (shown in green). A co-staining with an anti-von Willebrand factor antibody that stains blood vessels (red) and Dapi (blue) was performed. Abbreviations: SCC: squamous cell carcinoma; PA: pleomorphic adenoma.
Schwager, K., Villa, A., Rösli, C., Neri, D., Rösli-Khabas, M., & Moser, G. (2011). A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer. Head & neck oncology, 3(1), 25.
FuncS
Figure 10 Analysis of staining intensities.
Comparison of staining intensities obtained with the antibodies F8, L19 and F16 in A) primary tumours and metastasis tumour samples and in B) primary benign and primary maligant tumour specimens. C) Average staining intensities of tumours of the oral cavity, the pharynx or the larynx. Standard Errors of the Mean of scoring values are displayed.
Schwager, K., Villa, A., Rösli, C., Neri, D., Rösli-Khabas, M., & Moser, G. (2011). A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer. Head & neck oncology, 3(1), 25.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- IHC, FuncS, IF
- Related Disease
- Hematologic Malignancies; Solid Tumors
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Applications
- Application Notes
- The antibody was validated for Immunohistochemistry, Function Assay, Immunofluorescence. For details, refer to Published Data.
Target
- Alternative Names
- TNC; tenascin C; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225; tenascin; GP 150-225; cytotactin; neuronectin; myotendinous antigen; hexabrachion (tenascin); tenascin-C isoform 14/AD1/16; tenascin-C additional domain 1; deafness, autosomal dominant 56; glioma-associated-extracellular matrix antigen
- Gene ID
- 3371
- UniProt ID
- B4E1W8
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-877 | Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) | IHC | IgG2b |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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