Anti-Human TNC Recombinant Antibody (F16-131I)
CAT#: TAB-622CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human TNC. The monoclonal antibodiess F16-131I specific to F16 (specific to the A1 domain of tenascin-C) are currently investigated in Phase I and Phase II clinical trials in patients with cancer and with rheumatoid arthritis.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
❮
❯
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Hematologic Malignancies; Solid Tumors
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- TNC; tenascin C; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225; tenascin; GP 150-225; cytotactin; neuronectin; myotendinous antigen; hexabrachion (tenascin); tenascin-C isoform 14/AD1/16; tenascin-C additional domain 1; deafness, autosomal dominant 56; gli
- Gene ID
- 3371
- UniProt ID
- B4E1W8
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAB-622CL. Click the button above to contact us or submit your feedback about this product.
Reliable Research Tool
I have been using the Anti-TNC Therapeutic Antibody F16-131I in my research for over six months, and the results have been consistently reliable. The antibody binds specifically to TNC, which is critical in studying tumors. Its I-131 label enhances detection in imaging assays, and I have observed excellent consistency across multiple batches. This tool has become indispensable for our studies on tumor microenvironments and extracellular matrix remodeling, and it has significantly improved the clarity of our experimental data.
Robust Performance
This antibody has consistently provided robust performance across our research projects. Its ability to accurately detect the TNC antigen has been highly beneficial when analyzing cancer models and cell culture systems. The enhanced detection enabled by the I-131 label has improved our imaging studies, ensuring that our data is both precise and repeatable.
Q&As
-
What does the Anti-TNC Therapeutic Antibody F16-131I target and how is it used in research?
A: This antibody is designed to bind to the TNC (Tenascin-C) antigen, a protein that is often overexpressed in the extracellular matrix of tumors and involved in tissue remodeling. It is used in research to study the behavior and distribution of TNC in various cancers and tissue models. The product is part of a high-quality recombinant portfolio and is radiolabeled with I-131 to facilitate tracking and detection in experimental settings.
-
Why is the TNC antigen an important target in research, particularly in cancer studies?
A: TNC, or Tenascin-C, is an extracellular matrix protein that is significantly upregulated in many types of tumors. Studying TNC helps researchers understand its role in influencing cell adhesion, migration, and tissue invasion during cancer progression. The Anti-TNC Therapeutic Antibody F16-131I enables precise detection and quantification of TNC in tumor samples, providing insights into its potential as a marker for tumor aggression and as a tool to study matrix remodeling in cancer research.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-622CL, RRID: AB_3111980)
Copy citation
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Tnc"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1379z | Mouse Anti-TNC Recombinant Antibody (clone 22B10) | WB, IP, IF, IHC, ELISA | Mouse IgG1 |
| MOB-2007CT | Recombinant Mouse anti-Human TNC Monoclonal antibody (C764N) | IHC-Fr, IHC-P | |
| HPAB-0320CQ | Mouse Anti-TNC Recombinant Antibody (HPAB-0320CQ) | ELISA, WB, FuncS | Mouse IgG1, κ |
| HPAB-0190-WJ | Human Anti-TNC Recombinant Antibody (HPAB-0190-WJ) | ELISA | Human IgE |
| HPAB-N0264-YC | Human Anti-TNC Recombinant Antibody (HPAB-N0264-YC) | ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-877 | Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) | IHC | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-587CT | Human Anti-TNC Recombinant Antibody (TAB-587CT) | ELISA, FC | Human IgG4 |
| TAB-588CT | Human Anti-TNC Recombinant Antibody (TAB-588CT) | ELISA, FC | Human IgG4 |
| TAB-589CT | Human Anti-TNC Recombinant Antibody (TAB-589CT) | ELISA, FC | Human IgG4 |
| TAB-590CT | Human Anti-TNC Recombinant Antibody (TAB-590CT) | ELISA, FC | Human IgG4 |
| TAB-591CT | Anti-Human Tenascin C Recombinant Antibody (2B10) | ELISA, IF | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0810MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| BRD-0910MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2050CQ | Rat Anti-TNC Recombinant Antibody (clone CBL402) | WB, ICC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3601 | Rabbit Anti-TNC Recombinant Antibody (clone DS3601AB) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2108 | PE-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM | |
| MHC-LC2109 | APC-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-S(P) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| HPAB-0443-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0443-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0444-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0444-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0445-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0445-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0320CQ-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0320CQ-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-F(E) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| HPAB-AP203-YC-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-AP203-YC-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-AP204-YC-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-AP204-YC-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-N0264-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-N0264-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-N0265-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-N0265-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-877 | Afuco™ Anti-TNC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-877) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0083-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0083-YJ-VHH) | ELISA, IF | Camelid VHH |
| NBD-0084-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0084-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| NBD-0085-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0085-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY187 | Human Anti-TNC (clone F16-131I) scFv-Fc Chimera | IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2312 | Anti-TNC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7346 | Anti-Human TNC Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application: WB, ELISA, FuncS
Application: WB, IF, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: FC, ADCC, CDC, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
-4.jpg)
Application: FC, FuncS, IA, IF, IP, IHC
Application: Neut, IHC, Activ, FuncS, IF, ELISA
-4.jpg)
Application: FC
Application: ELISA, FC, WB, Inhib, IHC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
