BV421-DRB3*01:01/Human ITGB3 (AWRSDEALPLGS) MHC Tetramer
CAT#: MHC-LC1372
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of ITGB3-derived peptide of AWRSDEALPLGS covering 53-61 and DRB3*01:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/281_B9_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/ihc_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/64673_B_4_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (EFO-21, HEL, RPTEC TERT1, U-87 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000259207-ITGB3
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Specifications
- Allele
- DRB3*01:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- ITGB3
- Antigen Species
- Human
- Peptide
- AWRSDEALPLGS
- Range
- 53-61
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
- Alternative Names
- ITGB3; integrin subunit beta 3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
- Gene ID
- 3690
- UniProt ID
- P05106
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Datasheet
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COA
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