Anti-Human Integrin lpha 2b beta 3 Recombinant Antibody Fab Fragment (Tadocizumab) (CAT#: TAB-109-F(E))
Recombinant monoclonal antibody Fragment Fab to integrin alpha 2b + beta 3. Tadocizumab is a humanized monoclonal antibody that acts on the cardiovascular system.It binds to integrin αIIbβ3, a fibrinogen and fibronectin receptor found on platelets. The drug is designed for the treatment of patients undergoing percutaneous coronary interventions.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/281_B9_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/281_B9_2_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/ihc_selected.jpg
Figure 3 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/64673_B_4_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/64673_B_4_4.jpg
Figure 4 RNA cell line category: Cell line enhanced (EFO-21, HEL, RPTEC TERT1, U-87 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000259207-ITGB3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000259207-ITGB3
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- Fab - G1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
- CAS
- 339086-80-5
- Generic Name
- Tadocizumab
- UNII
- R34T642CGV
- MW
- 47.6 kDa
- Related Disease
- Platelet aggregation
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- Tadocizumab;339086-80-5;YM337;C4G1;ITGB3;integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61);GP3A;integrin beta-3;CD61;GPIIIa;platelet glycoprotein IIIa;platelet membrane glycoprotein IIIa;GT;BDPLT2;
- Gene ID
- 3690
- UniProt ID
- P05106
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-785-sdAb | Recombinant Anti-human ITGB3 VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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