BV421-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer
CAT#: MHC-LC1207
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Insr-derived peptide of GNYSFYAL covering 423-430 and H-2Kb molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg
Normal Tissue
Figure 8 Skeletal muscle
Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
❮
❯
Specifications
- Allele
- H-2Kb
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Insr
- Antigen Species
- Mouse
- Peptide
- GNYSFYAL
- Range
- 423-430
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis.
- Alternative Names
- Insr; insulin receptor; IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
- Gene ID
- 16337
- UniProt ID
- P15208
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Related Signaling Pathways
PPAR Signaling Pathway
Related Diseases
Type I Diabetes Mellitus
Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "INSR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441CL | Human Anti-INSR Recombinant Antibody (TAB-441CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-246 | Mouse Anti-INSR Recombinant Antibody (clone 83-7); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-2351LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2351LY-S(P)) | ELISA, WB | Humanized scfv |
| HPAB-2352LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2352LY-S(P)) | ELISA, WB | Humanized scfv |
| HPAB-2353LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2353LY-S(P)) | ELISA, WB | Humanized scfv |
| HPAB-2354LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2354LY-S(P)) | ELISA, WB | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-246 | Mouse Anti-INSR Recombinant Antibody (clone 83-7); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBZ-083 | Mouse Anti-INSR Recombinant Antibody (clone 83-14); Fab Fragment | WB, FuncS | Mouse Fab |
| HPAB-0129-YC-F(E) | Mouse Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-0129-YC-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2351LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2351LY-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-2352LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2352LY-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-711LC | Human Anti-INSR Recombinant Antibody (TAB-711LC) | ELISA, FC, FuncS | Human IgG |
| TAB-712LC | Human Anti-INSR Recombinant Antibody (TAB-712LC) | ELISA, FC, Agonist, FuncS | Human IgG |
| TAB-711LC-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (TAB-711LC-S(P)) | ELISA, FC | Human scFv |
| TAB-712LC-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (TAB-712LC-S(P)) | ELISA, FC | Human scFv |
| TAB-711LC-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (TAB-711LC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-124 | Recombinant Mouse Anti-IR Antibody (Fab83-14) | Neut, FuncS | IgG |
| PABX-125 | Recombinant Mouse Anti-IR Antibody (Fab83-7) | WB, ELISA, FuncS | IgG |
| PABX-124-F (E) | Recombinant Mouse Anti-IR Antibody Fab Fragment (Fab83-14 ) | Neut, FuncS | Fab |
| PABX-125-F (E) | Recombinant Mouse Anti-IR Antibody Fab Fragment (Fab83-7 ) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1205 | PE-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM | |
| MHC-LC1206 | APC-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1533CQ | Mouse Anti-INSR Recombinant Antibody (NEUT-1533CQ) | Inhib, IP | Mouse IgG2a |
| NEUT-1535CQ | Mouse Anti-INSR Recombinant Antibody (clone 47-9) | FC, Block, WB | Mouse IgG1 |
| NEUT-1536CQ | Mouse Anti-INSR Recombinant Antibody (clone 18-44) | FC, ICC, IF, Block, FuncS, IP, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1534CQ | Mouse Anti-INSR Recombinant Antibody (clone 29B4) | IP, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1844 | Rabbit Anti-INSR Recombinant Antibody (clone DS1844AB) | ICC, IP, WB | Rabbit IgG |
| MOR-4630 | Rabbit Anti-INSR Recombinant Antibody (clone TH143DS) | WB | Rabbit IgG |
| MOR-4688 | Rabbit Anti-INSR Recombinant Antibody (clone TH202DS) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1171CQ | Human Anti-INSR Recombinant Antibody (clone IR 18-146) | FC | Human IgG1 |
| FAMAB-1172CQ | Human Anti-INSR Recombinant Antibody (clone IR 47-46) | Block, IB, IP | Human IgG1 |
| FAMAB-1173CQ | Human Anti-INSR Recombinant Antibody (clone IR 83-22) | IB, Inhib, IP | Human IgG1 |
| FAMAB-1174CQ | Human Anti-INSR Recombinant Antibody (clone IR 25-49) | Block, IP, Stim | Human IgG1 |
| FAMAB-1175CQ | Human Anti-INSR Recombinant Antibody (clone IR 18-40) | IB, IP | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY155 | AbPlus™ Anti-INSR Magnetic Beads (1.B.109) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY148 | CytoStream™ Mouse Anti-INSR Recombinant Antibody (VS-0225-XY148) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY78 | Mouse Anti-INSR scFv-Fc Chimera (VS-0325-FY78) | IA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC382 | Recombinant Anti-INSR Vesicular Antibody, EV Displayed (VS-0425-YC382) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3571 | Anti-INSR Immunohistochemistry Kit | IHC | |
| VS-0525-XY3572 | Anti-Human INSR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC114 | Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46) | ELISA | Tandem scFv |
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