BV421-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer (CAT#: MHC-LC1207)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Insr-derived peptide of GNYSFYAL covering 423-430 and H-2Kb molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg
Figure 2 IHC staining of human liver
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg
Figure 4 Colon
(landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg
(landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg
Figure 5 Liver
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg
Figure 6 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg
Figure 7 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg
Figure 8 Skeletal muscle
(Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg
(Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg
Figure 9 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
Specifications
- Allele
- H-2Kb
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Insr
- Antigen Species
- Mouse
- Peptide
- GNYSFYAL
- Range
- 423-430
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis.
- Alternative Names
- Insr; insulin receptor; IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
- Gene ID
- 16337
- UniProt ID
- P15208
Related Resources
PPAR Signaling Pathway
Type I Diabetes Mellitus
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441CL | Human Anti-INSR Recombinant Antibody (TAB-441CL) | ELISA | Human IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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