Chicken Anti-CDK4 Polyclonal IgY
CAT#: BRD-0113MZ
This antibody is a chicken polyclonal antibody which specifically reacts with CDK4.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli, nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6024/1704_B1_1_cr5811e29350250_selected.jpg
Normal Tissue
Figure 2 IHC staining of human ovary
Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_4_7_selected.jpg
Normal Tissue
Figure 3 IHC staining of human endometrium
Immunohistochemical staining of human endometrium shows moderate nuclear positivity in cells in endometrial stroma.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69405/163411_B_5_3_selected.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HBEC3-KT, LHCN-M2, RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135446-CDK4
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Specifications
- Immunogen
- Recombinant protein Cyclin-dependent kinase 4
- Host Species
- Chicken
- Type
- Chicken antibody
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB
Target
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Crucial for Cell Cycle Research
The Chicken Anti-CDK4 Antibody has been instrumental in our cell cycle studies. Its specificity and sensitivity allow us to detect CDK4 with great accuracy, facilitating our research into its regulatory roles and interactions in cancer cells.
Broad Research Applications
Its application versatility extends its usefulness to numerous research areas, including cancer biology and cell cycle studies. This adaptability solidifies its place as a staple in our laboratory toolkit.
Q&As
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Why is the choice of chicken as the host species advantageous for antibody production?
A: Using chicken can provide antibodies that recognize epitopes distinct from those recognized by mammalian antibodies, reducing background noise and improving specificity in detecting CDK4 in various assays.
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What makes this antibody an excellent tool for cancer research?
A: CDK4 is involved in the regulation of the cell cycle, and its dysregulation is a hallmark of many cancers. This antibody aids in investigating the mechanisms of cell cycle control and the development of CDK4 inhibitors for cancer therapy.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
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Related Signaling Pathways
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CDK4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0630 | Hi-Affi™ Rabbit Anti-CDK4 Recombinant Antibody (clone DS630AB) | ICC, IF, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0339-CN | Mouse Anti-CDK4 Recombinant Antibody (clone 5-C3-G3) | WB, IF, IHC | Mouse IgG2c |
| MRO-0340-CN | Rabbit Anti-CDK4 Recombinant Antibody (clone CBACN-138) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-0341-CN | Rabbit Anti-CDK4 Recombinant Antibody (clone CBACN-139) | WB, IF, IP | Rabbit IgG |
| VS4-WK100 | Mouse Anti-CDK4 Recombinant Antibody (VS4-WK100) | ELISA, WB, ICC | Mouse IgG1 |
| VS7-HM675 | Mouse Anti-CDK4 Recombinant Antibody (clone 4A11E2) | IHC, ICC, FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC569 | AbPlus™ Anti-CDK4 Magnetic Beads (VS-0724-YC569) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY404 | Anti-CDK4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1317 | Anti-Mouse CDK4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1316 | Anti-Human CDK4 Immunohistochemistry Kit | IHC |
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