Anti-5T4 (clone H8)-AcBut-CalichDMH ADC
CAT#: ADC-231CL
This ADC product is composed of an anti-5T4 antibody (clone H8) conjugated via AcBut linker to CalichDMH (H8-AcBut-CalichDMH). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of DNA-damage.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/if_selected.jpg
Normal Tissue
Figure 2 Seminal vesicle
High expression in seminal vesicle
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_7_6_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_8_5.jpg
Normal Tissue
Figure 7 Placenta
Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_2_7.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000146242-TPBG
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Specifications
- Antibody Overview
- Murine H8 Antibody
- Clone
- H8
- Linker
- AcBut (4-(4'acetylphenoxy)butanoic acid)
- Linker Class/Description
- Class: Chemically cleavable linkers-Acid-labile linkers
Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
- Drug
- CalichDMH (Calicheamicin (CM))
- Drug Class/Description
- Class: Calicheamicin
Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
Target
- Introduction
- This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
- Alternative Names
- TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; 5T4 oncofetal trophoblast glycoprotein;
- Gene ID
- 7162
- UniProt ID
- Q13641
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Datasheet
MSDS
COA
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-118-F(E) | Anti-Human 5T4 Recombinant Antibody Fab Fragment, 5T4 (TAB-118-F(E)) | FuncS, IF, Neut, ELISA, FC, IP, ICC | Fab - G1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3649 | Rabbit Anti-TPBG Recombinant Antibody (clone DS3649AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ | Human Anti-TPBG Recombinant Antibody (HPAB-0088CQ) | ELISA, FC, FuncS | Human IgG1, κ |
| HPAB-0089CQ | Human Anti-TPBG Recombinant Antibody (HPAB-0089CQ) | ELISA, FC, FuncS | Human IgG1, κ |
| HPAB-0090CQ | Human Anti-TPBG Recombinant Antibody (HPAB-0090CQ) | ELISA, FC, FuncS | Human IgG1, κ |
| HPAB-0091CQ | Mouse Anti-TPBG Recombinant Antibody (HPAB-0091CQ) | ELISA, FC, FuncS | Mouse IgG, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0088CQ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0089CQ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0089CQ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0090CQ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0090CQ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0091CQ-S(P) | Mouse Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0091CQ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0092CQ-S(P) | Mouse Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0092CQ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0088CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0089CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0089CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0090CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0090CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0091CQ-F(E) | Mouse Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0091CQ-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0092CQ-F(E) | Mouse Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0092CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1281 | PE-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1282 | APC-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1283 | FITC-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1284 | H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC |
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| VS-0125-FY114 | Human Anti-TPBG (clone ASN004) scFv-Fc Chimera | ELISA, FC, FuncS | Human IgG1, scFv-Fc |
| VS-0425-FY60 | Human Anti-TPBG (clone H8) scFv-Fc Chimera | FC, ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC638 | Recombinant Anti-TPBG Vesicular Antibody, EV Displayed (VS-0425-YC638) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7454 | Anti-TPBG Immunohistochemistry Kit | IHC | |
| VS-0525-XY7455 | Anti-Mouse TPBG Immunohistochemistry Kit | IHC |
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