Anti-5T4 (clone H8)-AcBut-CalichDMH ADC (CAT#: ADC-236CL)

This ADC product is composed of an anti-5T4 antibody (clone H8) conjugated via AcBut linker to CalichDMH (H8PEGmal2-AcBut-CalichDMH). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of DNA-damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • PEGylated H8 Antibody
  • Clone
  • H8
  • Linker
  • AcBut (4-(4'acetylphenoxy)butanoic acid)
  • Linker Class/Description
  • Class: Chemically cleavable linkers-Acid-labile linkers
    Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
  • Drug
  • CalichDMH (Calicheamicin (CM))
  • Drug Class/Description
  • Class: Calicheamicin
    Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

Target

  • Introduction
  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
  • Alternative Names
  • TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; 5T4 oncofetal trophoblast glycoprotein;

Downloads

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Recombinant Antibody

Mouse Antibody

CAT Product Name Application Type
TAB-118-F(E) Anti-Human 5T4 Recombinant Antibody Fab Fragment, 5T4 (Naptumomab Estafenatox) FuncS, IF, Neut, ELISA, FC, IP, ICC Fab - G1 - kappa

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3649 Rabbit Anti-TPBG Recombinant Antibody (clone DS3649AB) WB, ICC, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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