Anti-5T4 (clone H8)-Amide-CalichDMH ADC (CAT#: ADC-233CL)

• Antibody Overview
• Murine H8 Antibody

• Clone
• H8

• Linker
• Amide (4-mercapto-4-methyl-pentanoic acid)

• Drug
• CalichDMH (Calicheamicin (CM))

• Drug Class/Description
• Class: Calicheamicin
  Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

• Introduction
• This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

• Alternative Names
• TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; 5T4 oncofetal trophoblast glycoprotein;

• Gene ID
• 7162

• UniProt ID
• Q13641

• ADC-231CL
• Anti-5T4 (clone H8)-AcBut-CalichDMH ADC

• ADC-232CL
• Anti-5T4 (clone H8)-AcPac-CalichDMH ADC

• ADC-234CL
• Anti-5T4 (clone H8)-AcBut-CalichDMH ADC

• ADC-235CL
• Anti-5T4 (clone H8)-AcBut-CalichDMH ADC

• ADC-236CL
• Anti-5T4 (clone H8)-AcBut-CalichDMH ADC

• HPAB-0096CQ
• Human Anti-TPBG Recombinant Antibody (clone H8)

• HPAB-0096CQ-S(P)
• Human Anti-TPBG Recombinant Antibody (clone H8); scFv Fragment

• HPAB-0096CQ-F(E)
• Human Anti-TPBG Recombinant Antibody (clone H8); Fab Fragment

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