PE-DQB1*03:02/Human TPO (IDVWLGGLAENFLP) MHC Tetramer (CAT#: MHC-LC4548)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human TPO of peptide IDVWLGGLAENFLP covering 632-645 and DQB1*03:02 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Normal Tissue
RNA Expression
Figure 1 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7987/21449_B_2_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7987/21449_B_2_5.jpg
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115705-TPO/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115705-TPO/subcellular
Specifications
- Allele
- DQB1*03:02
- Class
- Class II
- MHC Species
- Human
- Antigen
- TPO
- Antigen Species
- Human
- Peptide
- IDVWLGGLAENFLP
- Range
- 632-645
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
- Alternative Names
- TPO; Thyroid peroxidase; MSA; TPX; TDH2A
- Gene ID
- 7173
- UniProt ID
- P07202
Related Resources
Autoimmune Thyroid Disease
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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