PE-DQB1*03:02/Human TPO (IDVWLGGLAENFLP) MHC Tetramer
CAT#: MHC-LC4548
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human TPO of peptide IDVWLGGLAENFLP covering 632-645 and DQB1*03:02 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7987/21449_B_2_5.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115705-TPO/subcellular
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Specifications
- Allele
- DQB1*03:02
- Class
- Class II
- MHC Species
- Human
- Antigen
- TPO
- Antigen Species
- Human
- Peptide
- IDVWLGGLAENFLP
- Range
- 632-645
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
- Alternative Names
- TPO; Thyroid peroxidase; MSA; TPX; TDH2A
- Gene ID
- 7173
- UniProt ID
- P07202
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Related Diseases
Autoimmune Thyroid Disease
Downloadable Resources
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Datasheet
MSDS
COA
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