Recombinant Anti-TPO (Domain VI x Domain VIII) Biparatopic Antibody, Tandem scFv (Clone B8 x Clone A12)
CAT#: VS-0525-YC188
This biparatopic antibody (bpAb) is designed to target two distinct epitopes of TPO. Its tandem scFv architecture features the B8 scFv (specific for domain VI) N-terminally fused to the A12 scFv (recognizing domain VIII).
Gene Expression
Normal Tissue
Figure 1 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7987/21449_B_2_5.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115705-TPO/subcellular
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human TPO
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- B8
- Clone 2
- A12
- Epitope 1
- Domain VI
- Epitope 2
- Domain VIII
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, IHC, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Thyroid Peroxidase
Target
- Introduction
- This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
- Alternative Names
- MSA; TPX; TDH2A
- Gene ID
- 7173
- UniProt ID
- P07202
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Related Diseases
Autoimmune Thyroid Disease
Downloadable Resources
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
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