Human Anti-TPO Recombinant Antibody (clone TR1.9) (CAT#: PABW-123)
Autoantibody
Recombinant Human Antibody (TR1. 9) is capable of binding to TPO (thyroid peroxidase), expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TPO (thyroid peroxidase) mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TPO mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Inhib
Figure 1 mAb 47 inhibits the binding of human Fab TR1.9 to human TPO.
Competitive ELISA experiments were performed with mouse mAb 47 or 6H7 (control) as competitor for the binding of human Fab TR1.9 to TPO.
Bresson, D., Pugnière, M., Roquet, F., Rebuffat, S. A., Brigitte, N., Cerutti, M., ... & Ruf, J. (2004). Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies. Journal of Biological Chemistry, 279(37), 39058-39067.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- TPO
- Clone
- TR1.9
- Applications
- Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition.
Target
- Alternative Names
- TPO; thyroid peroxidase; MSA; TPX; TDH2A; thyroperoxidase; thyroid microsomal antigen
- Gene ID
- 7173
- UniProt ID
- P07202
Related Resources
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-999 | Recombinant Anti-TPO Antibody | ELISA, WB, FuncS | IgG |
| MOB-1174MZ | Recombinant Mouse Anti-Human TPO Antibody (clone NpBc58) | IHC-P | Mouse antibody |
| HPAB-2017-FY | Human Anti-TPO Recombinant Antibody (clone FY-019) | ELISA | Human IgG |
| ZG-0120C | Mouse Anti-TPO Recombinant Antibody (clone ABT-TPO) | IHC-P, IF | Mouse IgG |
| ZG-0121C | Mouse Anti-TPO Recombinant Antibody (clone PT0857) | WB | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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