Human Anti-TPO Recombinant Autoantibody (clone DN4) (CAT#: VS-1124-YJ3)
Autoantibody
Despite its low affinity, Fab DN4 bound specifically to TPO. Thus Fab DN4 gave a strong signal on ELISA wells coated with TPO, but not with the related enzymes LPO and MPO, Tg, and with two non-autoantigens, namely transferrin and KLH.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7987/21449_B_2_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7987/21449_B_2_5.jpg
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115705-TPO/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115705-TPO/subcellular
Specifications
- Host Species
- Human
- Type
- Human IgG1 kappa
- Species Reactivity
- Human
- Clone
- DN4
- Applications
- ELISA, FuncS
- Related Disease
- Autoimmune thyroid disease (AITD)
Product Property
- Purification
- See the COA
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Thyroid Peroxidase; EC 1.11.1.8; Thyroid Microsomal Antigen; Thyroperoxidase; EC 1.11.1; TDH2A; MSA; TPX
- Gene ID
- 7173
- UniProt ID
- P07202
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Related Resources
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1174MZ | Recombinant Mouse Anti-Human TPO Antibody (clone NpBc58) | IHC-P | Mouse antibody |
| FAMAB-0013JF | Human Anti-TPO Recombinant Antibody (clone A12) | WB, ELISA, IHC, Inhib | Human IgG |
| FAMAB-0014JF | Human Anti-TPO Recombinant Antibody (clone B8) | WB, ELISA, IHC | Human IgG |
| FAMAB-0015JF | Human Anti-TPO Recombinant Antibody (clone T5) | WB, ELISA, IHC, FC | Human IgG |
| FAMAB-0036JF | Human Anti-TPO Recombinant Antibody (clone TF3.5) | WB, ELISA, FC | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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