Recombinant Anti-TPO Vesicular Antibody, EV Displayed (VS-0425-YC757)
CAT#: VS-0425-YC757
The Recombinant Anti-TPO Vesicular Antibody, EV Displayed (VS-0425-YC757) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TPO-expressed cells or tissues. TPO is a glycoprotein enzyme involved in thyroid hormone synthesis, with mutations causing congenital hypothyroidism and related disorders.
Gene Expression
Normal Tissue
Figure 1 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7987/21449_B_2_5.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115705-TPO/subcellular
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TPO
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Thyroid peroxidase
- Biological Process
- Hydrogen peroxide, Thyroid hormones biosynthesis
- Molecular Function
- Oxidoreductase, Peroxidase
- Introduction
- This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
- Alternative Names
- TPX
- Gene ID
- 7173
- UniProt ID
- P07202
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Related Diseases
Autoimmune Thyroid Disease
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-999 | Recombinant Anti-TPO Antibody | ELISA, WB, FuncS | IgG |
| HPAB-2017-FY | Human Anti-TPO Recombinant Antibody (clone FY-019) | ELISA | Human IgG |
| FAMAB-0036JF | Human Anti-TPO Recombinant Antibody (clone TF3.5) | WB, ELISA, FC | Human IgG |
| FAMAB-0042JF | Human Anti-TPO Recombinant Antibody (clone ICA5) | WB, ELISA, FuncS | Human IgG |
| VS3-CJ458 | Mouse Anti-TPO Recombinant Antibody (VS3-CJ458) | IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-999-F(E) | Recombinant Anti-TPO Antibody Fab Fragment | ELISA, Nert, FuncS | Fab |
| MHH-999-F(E) | Recombinant Human Anti-TPO Antibody Fab Fragment | IP, IF, FuncS | Fab |
| HPAB-2017-FY-F(E) | Human Anti-TPO Recombinant Antibody (clone FY-019); Fab Fragment | ELISA | Human Fab |
| FAMAB-0036JF-F(E) | Human Anti-TPO Recombinant Antibody (clone TF3.5); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| FAMAB-0042JF-F(E) | Human Anti-TPO Recombinant Antibody (clone ICA5); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-999-S(P) | Recombinant Anti-TPO Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| MHH-999-S(P) | Recombinant Human Anti-TPO Antibody scFv Fragment | WB, FC, FuncS | scFv |
| HPAB-2017-FY-S(P) | Human Anti-TPO Recombinant Antibody (clone FY-019); scFv Fragment | ELISA | Human scFv |
| FAMAB-0036JF-S(P) | Human Anti-TPO Recombinant Antibody (clone TF3.5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0042JF-S(P) | Human Anti-TPO Recombinant Antibody (clone ICA5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2215CQ | Mouse Anti-TPO Recombinant Antibody (clone CBL296) | Neut, ELISA | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3658 | Rabbit Anti-TPO Recombinant Antibody (clone DS3658AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4548 | PE-DQB1*03:02/Human TPO (IDVWLGGLAENFLP) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1124-YJ3 | Human Anti-TPO Recombinant Autoantibody (clone DN4) | ELISA, FuncS | Human IgG1 kappa |
| VS-1124-YJ4 | Human Anti-TPO Recombinant Autoantibody (clone TR1.41) | ELISA | Human IgG1 lambda |
| VS-1124-YJ14 | Human Anti-TPO Recombinant Autoantibody (clone RII-9) | ELISA | Human IgG1 |
| VS-1124-YJ15 | Human Anti-TPO Recombinant Autoantibody (clone RI-8) | ELISA | Human IgG1 |
| VS-1124-YJ16 | Human Anti-TPO Recombinant Autoantibody (clone RI-33) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7469 | Anti-TPO Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC188 | Recombinant Anti-TPO (Domain VI x Domain VIII) Biparatopic Antibody, Tandem scFv (Clone B8 x Clone A12) | ELISA, IHC, WB | Tandem scFv |
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