Recombinant Anti-Human IL7R Antibody (Fc glycosylation)
CAT#: Gly-130LC
This product is a rat monoclonal antibody with glycosylation site in Fc region. The antibody with reduced anti-drug immune response specficfically binds to human IL-7R and can be potentially used in the treatment of Type 1 diabetes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
❮
❯
Glyco-engineering
- Glycosylation site
- Asn297 in Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- IL-7R (Interleukin 6 receptor)
- Host Species
- Rat
- Type
- Rat antibody
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- 28G9
- Applications
- ELISA
Target
- Alternative Names
- IL7R; interleukin 7 receptor; ILRA; CD127; IL7RA; CDW127; IL-7R-alpha; interleukin-7 receptor subunit alpha; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6
- Related Disease
- Type 1 diabetes
- Gene ID
- 3575
- UniProt ID
- P16871
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for Gly-130LC. Click the button above to contact us or submit your feedback about this product.
Superior ADCC Potency
We utilized this glyco-engineered anti-IL7R antibody to evaluate Fc-mediated effector functions. The modified Fc profile resulted in enhanced recruitment of effector cells, providing a significantly more robust ADCC response compared to our in-house wild-type IgG.
Consistent ELISA Performance
We employed this recombinant antibody in an indirect ELISA to quantify IL7R binding kinetics. The results showed a remarkably stable dose-response curve and high signal intensity, confirming that the Fc-glycosylation modification does not interfere with the antigen-binding specificity required for sensitive immunoassays.
Q&As
-
How has the Fc region of this anti-IL7R antibody been modified?
A: This recombinant antibody has undergone Fc glycosylation engineering. This modification is intended to modulate the interaction between the antibody's Fc tail and Fc receptors on immune effector cells, which can significantly enhance or alter effector functions like Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in your experiments.
-
What are the potential research applications for this IL7R antibody?
A: This antibody targets the IL7 receptor and is suitable for ELISA. It is particularly useful for studying the role of IL7R in lymphocyte development and autoimmune diseases such as multiple sclerosis.
View the frequently asked questions answered by Creative Biolabs Support.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IL7R"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1342z | Mouse Anti-IL7R Recombinant Antibody (clone 35D11) | FC, IP, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-437CL | Human Anti-IL7R Recombinant Antibody (TAB-437CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-698LC | Rat Anti-IL7R Recombinant Antibody (TAB-698LC) | ELISA, FC, Inhib, ADCC, FuncS | Rat IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-699LC | Human Anti-IL7R Recombinant Antibody (TAB-699LC) | ELISA, FC, Inhib, ADCC | Chimeric (Rat/Human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-700LC | Human Anti-IL7R Recombinant Antibody (TAB-700LC) | ELISA, FC, Inhib, ADCC | Chimeric (Rat/Human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-698LC-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-698LC-S(P)) | ELISA, FC | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-699LC-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-699LC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-700LC-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-700LC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-698LC-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-698LC-F(E)) | ELISA, FC | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-699LC-F(E) | Human Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-699LC-F(E)) | ELISA, FC | Chimeric (Rat/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-131LC | Recombinant Anti-Human IL7R Antibody (Non-glycosylated) | ELISA | Chimeric antibody (rat/mouse) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2118MZ | Recombinant Mouse Anti-Human IL7R Antibody (clone 50242) | ELISA, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1511CQ | Mouse Anti-IL7R Recombinant Antibody (clone R34-34) | Neut, Flow, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1512CQ | Rat Anti-Il7r Recombinant Antibody (NEUT-1512CQ) | Block, FC | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1513CQ | Rat Anti-Il7r Recombinant Antibody (clone A7R34) | Block, FC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1816 | Rabbit Anti-IL7R Recombinant Antibody (clone DS1816AB) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0316-YC | Human Anti-IL7R Recombinant Antibody (HPAB-0316-YC) | ELISA, Block | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0316-YC-F(E) | Human Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-0316-YC-F(E)) | ELISA, Block | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0315-YC | Rat Anti-IL7R Recombinant Antibody (HPAB-0315-YC) | FuncS | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0316-YC-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0316-YC-S(P)) | ELISA, Block | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0315-YC-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0315-YC-S(P)) | FuncS | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0315-YC-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-0315-YC-F(E)) | FuncS | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0426-CN | Rat Anti-IL7R Recombinant Antibody (HPAB-0426-CN) | ELISA, FC, Block | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0426-CN-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0426-CN-S(P)) | ELISA, FC, Block | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0427-CN-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0427-CN-S(P)) | ELISA, FC, Block | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0429-CN-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0429-CN-S(P)) | ELISA, FC, Block | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0426-CN-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-0426-CN-F(E)) | ELISA, FC, Block | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0427-CN-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-0427-CN-F(E)) | ELISA, FC, Block | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0428-CN-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-0428-CN-F(E)) | ELISA, FC, Block | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY43 | Mouse Anti-IL7R (clone 1A11) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC100 | Recombinant Anti-IL7R Vesicular Antibody, EV Displayed (VS-0425-YC100) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3543 | Anti-Mouse IL7R Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC74 | Anti-IL7R Antibody Prodrug, Protease Activated (VS-1025-YC74) | ISZ, Cyt, FuncS |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
