Recombinant Anti-Human IL7R Antibody (Fc glycosylation)

Name: Recombinant Anti-Human IL7R Antibody (Fc glycosylation)
SKU: Gly-130LC
Rating: 5 (1 reviews)

CAT#: Gly-130LC

This product is a rat monoclonal antibody with glycosylation site in Fc region. The antibody with reduced anti-drug immune response specficfically binds to human IL-7R and can be potentially used in the treatment of Type 1 diabetes.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R

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Glyco-engineering

Glycosylation site
Asn297 in Fc region

Glycosylation Type
N-glycosylation

Activity
Reduced anti-drug immune response

Specifications

Target
IL-7R (Interleukin 6 receptor)

Host Species
Rat

Type
Rat antibody

Specificity
Human

Antibody Isotype
IgG1

Clone
28G9

Applications
ELISA

Target

Alternative Names
IL7R; interleukin 7 receptor; ILRA; CD127; IL7RA; CDW127; IL-7R-alpha; interleukin-7 receptor subunit alpha; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6

Related Disease
Type 1 diabetes

Gene ID
3575

UniProt ID
P16871

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Downloadable Resources

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Datasheet

Datasheet - Gly-130LC.pdf

MSDS

MSDS - Gly-130LC.pdf

COA

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