Recombinant Anti-Human IL7R Antibody (Fc glycosylation) (CAT#: Gly-130LC)
This product is a rat monoclonal antibody with glycosylation site in Fc region. The antibody 28G9 with reduced anti-drug immune response specficfically binds to human IL-7R and can be potentially used in the treatment of Type 1 diabetes.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line REH
(Immunofluorescent staining of human cell line REH shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg
(Immunofluorescent staining of human cell line REH shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
Glyco-engineering
- Glycosylation site
- Asn297 in Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- IL-7R (Interleukin 6 receptor)
- Host Species
- Rat
- Type
- Rat antibody
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- 28G9
- Applications
- ELISA
Target
- Alternative Names
- IL7R; interleukin 7 receptor; ILRA; CD127; IL7RA; CDW127; IL-7R-alpha; interleukin-7 receptor subunit alpha; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6
- Related Disease
- Type 1 diabetes
- Gene ID
- 3575
- UniProt ID
- P16871
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-437CL | Human Anti-IL7R Recombinant Antibody (TAB-437CL) | ELISA | Human IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-698LC | Rat Anti-IL7R Recombinant Antibody (TAB-698LC) | ELISA, FC, Inhib, ADCC, FuncS | Rat IgG |
| TAB-698LC-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-698LC-S(P)) | ELISA, FC | Rat scFv |
| TAB-698LC-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-698LC-F(E)) | ELISA, FC | Rat Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-699LC | Human Anti-IL7R Recombinant Antibody (TAB-699LC) | ELISA, FC, Inhib, ADCC | Chimeric (Rat/Human) IgG1 |
| TAB-700LC | Human Anti-IL7R Recombinant Antibody (TAB-700LC) | ELISA, FC, Inhib, ADCC | Chimeric (Rat/Human) IgG1 |
| TAB-699LC-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-699LC-S(P)) | ELISA, FC | Human scFv |
| TAB-699LC-F(E) | Human Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-699LC-F(E)) | ELISA, FC | Chimeric (Rat/Human) Fab |
| TAB-700LC-F(E) | Human Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-700LC-F(E)) | ELISA, FC | Chimeric (Rat/Human) Fab |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-131LC | Recombinant Anti-Human IL7R Antibody (Non-glycosylated) | ELISA | Chimeric antibody (rat/mouse) |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2118MZ | Recombinant Mouse Anti-Human IL7R Antibody (clone 50242) | ELISA, WB | Mouse antibody |
| HPAB-0316-YC | Human Anti-IL7R Recombinant Antibody (HPAB-0316-YC) | ELISA, Block | Human IgG |
| MRO-1971-CN | Rabbit Anti-IL7R Polyclonal Antibody (MRO-1971-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1972-CN | Rabbit Anti-IL7R Polyclonal Antibody (MRO-1972-CN) | WB, IHC, FC | Rabbit IgG |
| FN-127CQ | Mouse Anti-IL7R Recombinant Antibody (clone A7R 34) | FuncS, Block | Mouse IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1511CQ | Mouse Anti-IL7R Recombinant Antibody (clone R34-34) | Neut, Flow, IP | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1512CQ | Rat Anti-Il7r Recombinant Antibody (clone mAb0832) | Block, FC | Rat IgG2 |
| NEUT-1513CQ | Rat Anti-Il7r Recombinant Antibody (clone A7R34) | Block, FC | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1816 | Rabbit Anti-IL7R Recombinant Antibody (clone DS1816AB) | WB, FC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0315-YC-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0315-YC-S(P)) | FuncS | Rat scFv |
| HPAB-0426-CN-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0426-CN-S(P)) | ELISA, FC, Block | Rat scFv |
| HPAB-0427-CN-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0427-CN-S(P)) | ELISA, FC, Block | Rat scFv |
| HPAB-3175LY-S(P) | Mouse Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-3175LY-S(P)) | IHC, IP, FC, IF, ELISA, WB | Mouse scfv |
| HPAB-3176LY-S(P) | Mouse Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-3176LY-S(P)) | IHC, IP, FC, IF, ELISA, WB | Mouse scfv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0315-YC-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-0315-YC-F(E)) | FuncS | Rat Fab |
| HPAB-3175LY-F(E) | Mouse Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-3175LY-F(E)) | IHC, IP, FC, IF, ELISA, WB | Mouse Fab |
| HPAB-3176LY-F(E) | Mouse Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-3176LY-F(E)) | IHC, IP, FC, IF, ELISA, WB | Mouse Fab |
| HPAB-1471-FY-S(P) | Mouse Anti-IL7R Recombinant Antibody (clone 6C5); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-1472-FY-S(P) | Mouse Anti-IL7R Recombinant Antibody (clone 6A3); Fab Fragment | ELISA, FC | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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