Recombinant Anti-Human IL7R Antibody (Fc glycosylation) (CAT#: Gly-130LC)
This product is a rat monoclonal antibody with glycosylation site in Fc region. The antibody with reduced anti-drug immune response specficfically binds to human IL-7R and can be potentially used in the treatment of Type 1 diabetes.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line REH
(Immunofluorescent staining of human cell line REH shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg
(Immunofluorescent staining of human cell line REH shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
Glyco-engineering
- Glycosylation site
- Asn297 in Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- IL-7R (Interleukin 6 receptor)
- Host Species
- Rat
- Type
- Rat antibody
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- 28G9
- Applications
- ELISA
Target
- Alternative Names
- IL7R; interleukin 7 receptor; ILRA; CD127; IL7RA; CDW127; IL-7R-alpha; interleukin-7 receptor subunit alpha; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6
- Related Disease
- Type 1 diabetes
- Gene ID
- 3575
- UniProt ID
- P16871
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1342z | Mouse Anti-IL7R Recombinant Antibody (clone 35D11) | FC, IP, Neut | Mouse IgG1 |
| FN-127CQ | Mouse Anti-IL7R Recombinant Antibody (clone A7R 34) | FuncS, Block | Mouse IgG1 |
| FN-210CQ | Mouse Anti-IL7R Recombinant Antibody (clone CBL-1341) | FC, FuncS, IHC-Fr, IF, IP | Mouse IgG1, κ |
| HPAB-3175LY | Mouse Anti-IL7R Recombinant Antibody (HPAB-3175LY) | IHC, IP, FC, IF, ELISA, WB | Mouse IgG1 |
| HPAB-3176LY | Mouse Anti-IL7R Recombinant Antibody (HPAB-3176LY) | FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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