Mouse Anti-IL7R (clone 1A11) scFv-Fc Chimera
CAT#: VS-0425-FY43
The anti-IL7R scFv-Fc is a novel therapeutic antibody designed to target the interleukin-7 receptor (IL7R), which plays a critical role in immune system regulation and hematopoiesis. This fusion protein combines a single-chain variable fragment (scFv) with an Fc domain, enhancing its stability and extending its half-life in circulation. By blocking IL7R signaling, this product aims to modulate immune responses in various diseases, including autoimmune disorders and certain types of cancers. The anti-IL7R scFv-Fc demonstrates high specificity and affinity for its target, which is essential for effective therapeutic interventions. Preclinical studies have shown promising results in reducing pathological immune activity while preserving normal immune function. This product represents a significant advancement in targeted therapies, with the potential to offer new treatment options for patients with IL7R-related conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R
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Specifications
- Immunogen
- Full extracellular domain (ECD) of CD127 (amino acids 21-219).
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human IL7R
- Species Reactivity
- Human
- Clone
- 1A11
- Applications
- ELISA
- Related Disease
- Autoimmune or inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 7 Receptor
- Gene ID
- 3575
- UniProt ID
- P16871
- Long Name
- Interleukin 7 Receptor
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 4 subfamily.
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
Ubiquitinated by MARCHF8; leading to lysosomal degradation.
Glycosylation at Asn49, Asn65, Asn151, Asn182, Asn232, and Asn233
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- XP_047273105.1; XP_047273106.1; XP_054208497.1; XP_054208498.1; NP_001397663.1
- Function
- Receptor for interleukin-7.
Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 1A11"
- CAT
- Product Name
See other products for "IL7R"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-437CL | Human Anti-IL7R Recombinant Antibody (TAB-437CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-698LC | Rat Anti-IL7R Recombinant Antibody (TAB-698LC) | ELISA, FC, Inhib, ADCC, FuncS | Rat IgG |
| TAB-698LC-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-698LC-S(P)) | ELISA, FC | Rat scFv |
| TAB-698LC-F(E) | Rat Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-698LC-F(E)) | ELISA, FC | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-699LC | Human Anti-IL7R Recombinant Antibody (TAB-699LC) | ELISA, FC, Inhib, ADCC | Chimeric (Rat/Human) IgG1 |
| TAB-699LC-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-699LC-S(P)) | ELISA, FC | Human scFv |
| TAB-700LC-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (TAB-700LC-S(P)) | ELISA, FC | Human scFv |
| TAB-699LC-F(E) | Human Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-699LC-F(E)) | ELISA, FC | Chimeric (Rat/Human) Fab |
| TAB-700LC-F(E) | Human Anti-IL7R Recombinant Antibody; Fab Fragment (TAB-700LC-F(E)) | ELISA, FC | Chimeric (Rat/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-130LC | Recombinant Anti-Human IL7R Antibody (Fc glycosylation) | ELISA | Rat antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-131LC | Recombinant Anti-Human IL7R Antibody (Non-glycosylated) | ELISA | Chimeric antibody (rat/mouse) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2118MZ | Recombinant Mouse Anti-Human IL7R Antibody (clone 50242) | ELISA, WB | Mouse antibody |
| MRO-1971-CN | Rabbit Anti-IL7R Polyclonal Antibody (MRO-1971-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1972-CN | Rabbit Anti-IL7R Polyclonal Antibody (MRO-1972-CN) | WB, IHC, FC | Rabbit IgG |
| FAMAB-1205CQ | Human Anti-IL7R Recombinant Antibody (clone YIL7R417) | ELISA, FC | Human IgG1 |
| FAMAB-1206CQ | Human Anti-IL7R Recombinant Antibody (clone YIL7R323) | ELISA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1511CQ | Mouse Anti-IL7R Recombinant Antibody (clone R34-34) | Neut, Flow, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1512CQ | Rat Anti-Il7r Recombinant Antibody (NEUT-1512CQ) | Block, FC | Rat IgG2 |
| NEUT-1513CQ | Rat Anti-Il7r Recombinant Antibody (clone A7R34) | Block, FC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1816 | Rabbit Anti-IL7R Recombinant Antibody (clone DS1816AB) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0316-YC-F(E) | Human Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-0316-YC-F(E)) | ELISA, Block | Human Fab |
| HPAB-3175LY-F(E) | Mouse Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-3175LY-F(E)) | IHC, IP, FC, IF, ELISA, WB | Mouse Fab |
| HPAB-3176LY-F(E) | Mouse Anti-IL7R Recombinant Antibody; Fab Fragment (HPAB-3176LY-F(E)) | IHC, IP, FC, IF, ELISA, WB | Mouse Fab |
| HPAB-1471-FY-S(P) | Mouse Anti-IL7R Recombinant Antibody (clone 6C5); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-1472-FY-S(P) | Mouse Anti-IL7R Recombinant Antibody (clone 6A3); Fab Fragment | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0316-YC-S(P) | Human Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0316-YC-S(P)) | ELISA, Block | Human scFv |
| HPAB-0315-YC-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0315-YC-S(P)) | FuncS | Rat scFv |
| HPAB-0426-CN-S(P) | Rat Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-0426-CN-S(P)) | ELISA, FC, Block | Rat scFv |
| HPAB-3175LY-S(P) | Mouse Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-3175LY-S(P)) | IHC, IP, FC, IF, ELISA, WB | Mouse scfv |
| HPAB-3176LY-S(P) | Mouse Anti-IL7R Recombinant Antibody; scFv Fragment (HPAB-3176LY-S(P)) | IHC, IP, FC, IF, ELISA, WB | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC100 | Recombinant Anti-IL7R Vesicular Antibody, EV Displayed (VS-0425-YC100) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3543 | Anti-Mouse IL7R Immunohistochemistry Kit | IHC |
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