Recombinant Anti-Human TNF Antibody (Fc glycosylation) (CAT#: Gly-099LC)
This product is a chimeric (mouse/human) monoclonal antibody with glycoslyated site in Fc region. The antibody CNTO860 with reduced anti-drug immune response specifically binds TNFα and can be potentially used in the treatment of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Glyco-engineering
- Glycosylation site
- Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- TNFα (Tumor necrosis factor alpha)
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- CNTO860
- Expression Host
- YB2/0
- Applications
- ELISA
Target
- Alternative Names
- TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Related Disease
- Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TNF"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-051 | Recombinant Anti-human TNF VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-412CQ | Anti-Human TNF Therapeutic Single Domain Antibody (TAR1-5-19) | ELISA, Inhib | Single domain antibody |
| TAB-413CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL18) | ELISA, WB, Neut | Single domain antibody |
| TAB-414CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL11) | ELISA, WB, Neut | Single domain antibody |
| TAB-415CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL18-3L-VL11) | ELISA, WB, Neut, FunS | Single domain antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-768 | Anti-TNF alpha Recombinant Antibody (Nerelimomab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 |
| TAB-718 | Anti-TNFα Recombinant Antibody (Afelimomab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | F(ab')2 - G3 - kappa |
| TAB-311CT | Anti-Human TNFα/RANKL Recombinant Antibody (8G12) | Neut, ELISA, FC | |
| TAB-311CT-F(E) | Anti-Human TNFα/RANKL Recombinant Antibody Fab Fragment (8G12) | Neut, ELISA, FC | |
| TAB-271CQ-S(P) | Rabbit Anti-TNF Recombinant Antibody; scFv Fragment (TAB-271CQ-S(P)) | ELISA, WB | Rabbit scFv |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-623CL | Bovine Anti-TNF Recombinant Antibody (TAB-623CL) | Neut | Bovine IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-349 | Human Anti-TNF Recombinant Antibody (clone A2); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-M0219-YC-F(E) | Rabbit Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-M0219-YC-F(E)) | ELISA, Neut, Inhib, FuncS | Rabbit Fab |
| HPAB-M0220-YC-F(E) | Rabbit Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-M0220-YC-F(E)) | ELISA, Neut, Inhib, FuncS | Rabbit Fab |
| HPAB-M0221-YC-F(E) | Rabbit Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-M0221-YC-F(E)) | ELISA, Neut, Inhib, FuncS | Rabbit Fab |
| HPAB-M0222-YC-F(E) | Rabbit Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-M0222-YC-F(E)) | ELISA, Neut, Inhib, FuncS | Rabbit Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-124CQ | Human Anti-TNF Recombinant Antibody (TAB-124CQ) | FuncS, Neut | Humanized antibody |
| TAB-125CQ | Human Anti-TNF Recombinant Antibody (TAB-125CQ) | ELISA, Neut | Humanized antibody |
| TAB-126CQ | Human Anti-TNF Recombinant Antibody (TAB-126CQ) | ELISA, Neut | Humanized antibody |
| TAB-127CQ | Human Anti-TNF Recombinant Antibody (TAB-127CQ) | ELISA, Neut | Humanized antibody |
| TAB-128CQ | Human Anti-TNF Recombinant Antibody (TAB-128CQ) | ELISA, FuncS | Humanized antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-148CQ | Anti-Human TNF Recombinant Antibody | ELISA | Chimeric antibody (mouse/human) |
| TAB-148CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) | ELISA | Mouse scFv |
| TAB-148CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-111CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (B5) | ELISA, WB | Human antibody |
| TAB-113CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) | ELISA | Human Fab |
| TAB-119CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-119CQ-F(E)) | ELISA, BL | Human Fab |
| TAB-404CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (BPC1494) | ELISA, WB | Human antibody |
| TAB-405CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (XENP6401) | ELISA | Human antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-088LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA, FC | Human antibody |
| Gly-098LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-100LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
Non-hyper Galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
Sialylated IgG Glycan
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-085LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-163LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
Hyper-galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-086LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0609MZ | Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2057CQ | Rat Anti-Tnf Recombinant Antibody (clone XT3) | Block, ELISA, IHC, WB | Rat IgG1 |
| NEUT-2070CQ | Mouse Anti-TNF Recombinant Antibody (clone 4F4) | Block, ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
| NEUT-2071CQ | Rabbit Anti-TNF Recombinant Antibody (clone 6E10) | Block, ELISA, IHC, WB | Rabbit IgG1 |
| NEUT-2082CQ | Mouse Anti-TNF Recombinant Antibody (clone B-C7) | Block | Mouse IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2089CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL194) | IHC, Neut, WB | Mouse IgG1 |
| NEUT-2090CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL918) | ELISA, Neut | Mouse IgG2a |
| NEUT-2091CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL921) | ELISA, Neut, FC | Mouse IgG1 |
| NEUT-2092CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL923) | FC, IF, Neut, WB | Mouse IgG2b |
| NEUT-2108CQ | Mouse Anti-TNF Recombinant Antibody (clone mAb11) | ELISA, CyTOF, FC, ICFC, ICC, IF, IHC, Neut | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4460 | Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) | ELISA | Rabbit IgG |
| MOR-4461 | Rabbit Anti-TNF Recombinant Antibody (clone SI555DS) | Neut | Rabbit IgG |
| MOR-4462 | Rabbit Anti-TNF Recombinant Antibody (clone SI556DS) | FC | Rabbit IgG |
| MOR-4463 | Rabbit Anti-TNF Recombinant Antibody (clone SI557DS) | FC | Rabbit IgG |
| MOR-4464 | Rabbit Anti-TNF Recombinant Antibody (clone SI558DS) | FC | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-169CQ | Goat Anti-TNF Polyclonal Antibody, Biotin | WB, ELISA(Det), ICC | Goat IgG |
| MOB-170CQ | Mouse Anti-TNF Recombinant Antibody (clone YC146), Biotin | Neut, ELISA, ICC, FC | Mouse IgG1, κ |
| HPAB-0321CQ | Human Anti-TNF Recombinant Antibody (clone mAb A1) | ELISA, Neut | Human IgG |
| HPAB-0322CQ | Rat Anti-TNF Recombinant Antibody (HPAB-0322CQ) | WB, ELISA, Cyt, FuncS | Rat IgG |
| HPAB-0323CQ | Rat Anti-TNF Recombinant Antibody (HPAB-0323CQ) | ELISA, FuncS | Rat IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-768 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-006 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-010 | Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0247-YC-S(P) | Human Anti-TNF Recombinant Antibody (clone AP024/YC); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-J0248-YC-S(P) | Human Anti-TNF Recombinant Antibody (clone F6); scFv Fragment | ELISA, Neut | Human scFv |
| HPAB-1924-FY-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-1924-FY-F(E)) | ELISA | Human Fab |
| HPAB-1925-FY-F(E) | Mouse Anti-TNF Recombinant Antibody (clone Mab32); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0332JF-S(P) | Mouse Anti-TNF Recombinant Antibody (clone Di62); scFv Fragment | RIA, ELISA, FuncS | Mouse scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for Gly-099LC. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
© 2023 Creative Biolabs. All Rights Reserved.