Recombinant Anti-Human TNF Antibody (Fc glycosylation) (CAT#: Gly-099LC)
This product is a chimeric (mouse/human) monoclonal antibody with glycoslyated site in Fc region. The antibody CNTO860 with reduced anti-drug immune response specifically binds TNFα and can be potentially used in the treatment of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Glyco-engineering
- Glycosylation site
- Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- TNFα (Tumor necrosis factor alpha)
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- CNTO860
- Expression Host
- YB2/0
- Applications
- ELISA
Target
- Alternative Names
- TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Related Disease
- Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TNF"
Select a product category from the dropdown menu below to view related products.
Please select product type
Mouse Antibody
Rat Antibody
Humanized Antibody
Chimeric Antibody
Single-domain Antibody
Human Antibody
Fc Glycosylation
Non-hyper Galactosylated
Sialylated IgG Glycan
Hyper-galactosylated
Chicken IgY Antibody
Blocking Antibody
Neutralizing Antibody
Rabbit Monoclonal Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
Recombinant Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-718 | Anti-TNFα Recombinant Antibody (Afelimomab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | F(ab')2 - G3 - kappa |
| TAB-311CT-S(P) | Anti-Human TNFα/RANKL Recombinant Antibody scFv Fragment (8G12) | Neut, ELISA, FC | |
| TAB-311CT-F(E) | Anti-Human TNFα/RANKL Recombinant Antibody Fab Fragment (8G12) | Neut, ELISA, FC | |
| TAB-271CQ | Rabbit Anti-TNF Recombinant Antibody (TAB-271CQ) | ELISA, Neut | Rabbit IgG |
| TAB-139CQ-S(P) | Rabbit Anti-TNF Recombinant Antibody; scFv Fragment (TAB-139CQ-S(P)) | ELISA, FC, IF | Rabbit scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for Gly-099LC. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: WB, ELISA, FuncS
Application: ELISA
Application: ELISA, FC, WB, FuncS
Application: ELISA, Inhib, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
