Human Anti-TNF Recombinant Antibody (clone cA2); scFv Fragment (CAT#: HPAB-0007-YC-S(P))
TNF causes pro-inflammatory actions which result in tissue injury, such as inducing procoagulant activity on vascular endothelial cells, increasing the adherence of neutrophils and lymphocytes, and stimulating the release of platelet activating factor from macrophages, neutrophils and vascular endothelial cells. Neutralizing to TNF have been shown in mammals other than man to abrogate adverse physiological changes and prevent death after lethal challenge in experimental endotoxemia and bacteremia.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Specifications
- Host Species
- Human
- Type
- Mouse scFv
- Specificity
- Human TNF
- Species Reactivity
- Human
- Clone
- cA2
- Applications
- ELISA, Neut
- Related Disease
- TNFα-mediated pathologies
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone cA2"
See other products for "TNF"
Select a product category from the dropdown menu below to view related products.
Please select product type
Single-domain Antibody
Mouse Antibody
Human Antibody
Rat Antibody
Humanized Antibody
Chimeric Antibody
Non-hyper Galactosylated
Sialylated IgG Glycan
Hyper-galactosylated
Fc Glycosylation
Chicken IgY Antibody
Blocking Antibody
Neutralizing Antibody
Rabbit Monoclonal Antibody
scFv Fragment Antibody
Recombinant Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-051 | Recombinant Anti-human TNF VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-412CQ | Anti-Human TNF Therapeutic Single Domain Antibody (TAB-412CQ) | ELISA, Inhib | Single domain antibody |
| TAB-413CQ | Anti-Human TNF Therapeutic Single Domain Antibody (TAB-413CQ) | ELISA, WB, Neut | Single domain antibody |
| TAB-414CQ | Anti-Human TNF Therapeutic Single Domain Antibody (TAB-414CQ) | ELISA, WB, Neut | Single domain antibody |
| TAB-415CQ | Anti-Human TNF Therapeutic Single Domain Antibody (TAB-415CQ) | ELISA, WB, Neut, FunS | Single domain antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-0007-YC-S(P). Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
-1.jpg)
Application: ELISA, WB
Application: ELISA, FuncS, Neut, IF, WB, EM, Inhib, IHC
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
