Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) (CAT#: Gly-083LC)
This product is a non-hypergalactosylated human monoclonal antibody with glycoslyated site in Fc region. The glycoengineered antibody has reduced anti-drug immune respone, it specifically binds TNFα and can be potentially used in the treatment of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Glyco-engineering
- Glycosylation site
- Asn297 at Fc region
- Glycoform (ratio)
- G0F (68%)
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- TNFα (Tumor necrosis factor alpha)
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- D2E7
- Applications
- ELISA, FC
Target
- Alternative Names
- TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Related Disease
- Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone D2E7"
See other products for "TNF"
Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibodies
Chimeric Antibodies
Rat Antibodies
Fab Antibodies
IgM Antibodies
Mouse Antibodies
Humanized Antibodies
Non-hyper Galactosylated Antibodies
Fc Glycosylation Antibodies
Sialylated IgG Glycan
Hyper-galactosylated Antibodies
Chicken IgY Antibodies
Blocking Antibodies
Neutralizing Antibodies
Rabbit Monoclonal Antibodies
IgG Antibodies
ADCC Enhanced Antibodies
ScFv Antibodies
Single Domain Antibodies
Antibody Magnetic Beads
ScFv-Fc Chimeras
FC Reagents & Kits
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010 | Anti-Human TNF Recombinant Antibody (TAB-010) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG1, κ |
| TAB-111CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (B5) | ELISA, WB | Human antibody |
| TAB-113CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) | ELISA | Human Fab |
| TAB-119CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-119CQ-F(E)) | ELISA, BL | Human Fab |
| TAB-120CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (TAB-120CQ-F(E)) | ELISA, Neut | Human antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for Gly-083LC. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: WB, IF, FuncS
Application: WB, ELISA, IF
Application: ELISA, WB, FC
Application: ELISA, FC, Neut, Inhib
-3.jpg)
Application: IB, FC, ELISA, FuncS
Application: ELISA, Inhib, FuncS
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
For Research Use Only. Not For Clinical Use.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
