Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) (CAT#: Gly-083LC)

This product is a non-hypergalactosylated human monoclonal antibody with glycoslyated site in Fc region. The glycoengineered antibody has reduced anti-drug immune respone, it specifically binds TNFα and can be potentially used in the treatment of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis.

Specific Inquiry
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  • Conjugation:

  • Endotoxin:

  • Purity:

  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Glyco-engineering

  • Glycosylation site
  • Asn297 at Fc region
  • Glycoform (ratio)
  • G0F (68%)
  • Glycosylation Type
  • N-glycosylation
  • Activity
  • Reduced anti-drug immune response

Specifications

  • Target
  • TNFα (Tumor necrosis factor alpha)
  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Antibody Isotype
  • IgG1
  • Clone
  • D2E7
  • Applications
  • ELISA, FC

Target

  • Alternative Names
  • TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
  • Related Disease
  • Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Downloads

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