Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) (CAT#: Gly-085LC)
This product is a sialylated human monoclonal antibody with glycoslyated site in Fc region. The glycoengineered antibody SA-D2E7 has reduced anti-drug immune respone, it specifically binds TNFα and can be potentially used in the treatment of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Glyco-engineering
- Glycosylation site
- Asn297 at Fc region
- Glycoform (ratio)
- G2S1F and G2S2F
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- TNFα (Tumor necrosis factor alpha)
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- SA- D2E7
- Applications
- ELISA, FC
Target
- Alternative Names
- TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Related Disease
- Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone SA- D2E7"
See other products for "TNF"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-051 | Recombinant Anti-human TNF VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-412CQ | Anti-Human TNF Therapeutic Single Domain Antibody (TAR1-5-19) | ELISA, Inhib | Single domain antibody |
| TAB-413CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL18) | ELISA, WB, Neut | Single domain antibody |
| TAB-414CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL11) | ELISA, WB, Neut | Single domain antibody |
| TAB-415CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL18-3L-VL11) | ELISA, WB, Neut, FunS | Single domain antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-006 | Anti-Human TNF Recombinant Antibody (Infliximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-402CQ | Human Anti-TNF Recombinant Antibody (TAB-402CQ) | ELISA | Chimeric (mouse/human) IgG |
| TAB-148CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) | ELISA | Mouse scFv |
| TAB-402CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-623CL | Bovine Anti-TNF Recombinant Antibody (TAB-623CL) | Neut | Bovine IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-311CT-S(P) | Anti-Human TNFα/RANKL Recombinant Antibody scFv Fragment (8G12) | Neut, ELISA, FC | |
| TAB-112CQ | Anti-Human TNF Recombinant Antibody (A10G10) | Neut, ELISA, WB | |
| TAB-116CQ | Anti-Human TNF Recombinant Antibody (Vh5/Vk12) | ELISA | |
| TAB-117CQ | Anti-Human TNF Recombinant Antibody (TSK114) | ELISA, WB | |
| TAB-271CQ-S(P) | Rabbit Anti-TNF Recombinant Antibody; scFv Fragment (TAB-271CQ-S(P)) | ELISA, WB | Rabbit scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-124CQ | Human Anti-TNF Recombinant Antibody (TAB-124CQ) | FuncS, Neut | Humanized antibody |
| TAB-125CQ | Human Anti-TNF Recombinant Antibody (TAB-125CQ) | ELISA, Neut | Humanized antibody |
| TAB-126CQ | Human Anti-TNF Recombinant Antibody (TAB-126CQ) | ELISA, Neut | Humanized antibody |
| TAB-127CQ | Human Anti-TNF Recombinant Antibody (TAB-127CQ) | ELISA, Neut | Humanized antibody |
| TAB-128CQ | Human Anti-TNF Recombinant Antibody (TAB-128CQ) | ELISA, FuncS | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-111CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (B5) | ELISA, WB | Human antibody |
| TAB-113CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) | ELISA | Human Fab |
| TAB-135CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (AE11-5) | ELISA, Neut | Human antibody |
| TAB-136CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-136CQ-F(E)) | ELISA, Block | Human Fab |
| TAB-137CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-137CQ-F(E)) | ELISA, FC, IF | Human Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
| Gly-086LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-088LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA, FC | Human antibody |
| Gly-098LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA | Human antibody |
Non-hyper Galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
Sialylated IgG Glycan
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-085LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-163LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
Hyper-galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-086LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0609MZ | Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2051CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL589) | ELISA, ICC, Neut | Mouse IgG1 |
| NEUT-2052CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL570) | WB, Neut | Mouse IgG2b |
| NEUT-2053CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL571) | WB, Neut | Mouse IgG1 |
| NEUT-2054CQ | Rat Anti-Tnf Recombinant Antibody (clone mAb0856) | Neut | Rat IgG1 |
| NEUT-2108CQ | Mouse Anti-TNF Recombinant Antibody (clone mAb11) | ELISA, CyTOF, FC, ICFC, ICC, IF, IHC, Neut | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2057CQ | Rat Anti-Tnf Recombinant Antibody (clone XT3) | Block, ELISA, IHC, WB | Rat IgG1 |
| NEUT-2070CQ | Mouse Anti-TNF Recombinant Antibody (clone 4F4) | Block, ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
| NEUT-2071CQ | Rabbit Anti-TNF Recombinant Antibody (clone 6E10) | Block, ELISA, IHC, WB | Rabbit IgG1 |
| NEUT-2082CQ | Mouse Anti-TNF Recombinant Antibody (clone B-C7) | Block | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3602 | Rabbit Anti-Tnf Recombinant Antibody (clone DS3602AB) | ELISA, WB | Rabbit IgG |
| MOR-4462 | Rabbit Anti-TNF Recombinant Antibody (clone SI556DS) | FC | Rabbit IgG |
| MOR-4463 | Rabbit Anti-TNF Recombinant Antibody (clone SI557DS) | FC | Rabbit IgG |
| MOR-4464 | Rabbit Anti-TNF Recombinant Antibody (clone SI558DS) | FC | Rabbit IgG |
| MOR-4465 | Rabbit Anti-TNF Recombinant Antibody (clone SI559DS) | FC | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0007-YC | Human Anti-TNF Recombinant Antibody (clone cA2) | ELISA, Neut | Chimeric (mouse/human) IgG1 |
| HPAB-0046-FY | Mouse Anti-TNF Recombinant Antibody (clone 1B7) | Neut | Mouse IgG |
| HPAB-1283LY | Human Anti-TNF Recombinant Antibody (clone CBL026) | ELISA | Human IgG |
| FN-013CQ | Mouse Anti-TNF Recombinant Antibody (clone J1D9) | FC, FuncS, WB | Mouse IgG1 |
| HPAB-2679LY | Mouse Anti-TNF Recombinant Antibody (HPAB-2679LY) | ELISA | Mouse IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0151-YC-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0151-YC-S(P)) | ELISA, Inhib, FuncS | Human scFv |
| HPAB-0587-WJ-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0587-WJ-S(P)) | ELISA | Human scFv |
| HPAB-1807-FY-F(E) | Human Anti-TNF Recombinant Antibody (clone AB164); scFv Fragment | Neut | Human scFv |
| HPAB-1808-FY-F(E) | Human Anti-TNF Recombinant Antibody (clone AB197); scFv Fragment | Neut | Human scFv |
| HPAB-1564WJ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (clone 3B10) | ELISA, WB, Neut | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0151-YC-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0151-YC-F(E)) | ELISA, Inhib, FuncS | Human Fab |
| HPAB-0046-FY-F(E) | Mouse Anti-TNF Recombinant Antibody (clone 1B7); Fab Fragment | Neut | Mouse Fab |
| HPAB-M0680-YC-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-M0680-YC-F(E)) | ELISA, Neut, Inhib | Humanized Fab |
| HPAB-M0681-YC-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-M0681-YC-F(E)) | ELISA, Neut, Inhib | Humanized Fab |
| HPAB-0203-WJ-F(E) | Rat Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0203-WJ-F(E)) | Neut, ELISA | Rat Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-768 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-006 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-010 | Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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