Human Anti-TNF Recombinant Antibody (clone cA2); Fab Fragment (CAT#: HPAB-0007-YC-F(E))
TNF causes pro-inflammatory actions which result in tissue injury, such as inducing procoagulant activity on vascular endothelial cells, increasing the adherence of neutrophils and lymphocytes, and stimulating the release of platelet activating factor from macrophages, neutrophils and vascular endothelial cells. Neutralizing to TNF have been shown in mammals other than man to abrogate adverse physiological changes and prevent death after lethal challenge in experimental endotoxemia and bacteremia.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Specifications
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human TNF
- Species Reactivity
- Human
- Clone
- cA2
- Applications
- ELISA, Neut
- Related Disease
- TNFα-mediated pathologies
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone cA2"
See other products for "TNF"
Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibody Products
Chimeric Antibody Products
Rat Antibody Products
Humanized Antibody Products
IgM Antibody Products
Mouse Antibody Products
Fc Glycosylation Antibody Products
Non-hyper Galactosylated Antibody Products
Sialylated IgG Glycan Products
Hyper-galactosylated Antibody Products
IgG Antibody Products
Chicken IgY Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
Fab Antibody Products
Single Domain Antibody Products
ADCC Enhanced Antibody Products
ScFv Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010 | Anti-Human TNF Recombinant Antibody (TAB-010) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG1, κ |
| TAB-254 | Anti-Human TNF Recombinant Antibody (Placulumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | [V-kappa]2 - Fc |
| TAB-395CQ | Anti-Human TNF Recombinant Antibody (BOW050) | ELISA | Human antibody |
| TAB-396CQ | Anti-Human TNF Recombinant Antibody (BOW100) | ELISA | Human antibody |
| TAB-397CQ | Human Anti-TNF Recombinant Antibody (TAB-397CQ) | ELISA | Human IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-0007-YC-F(E). Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, ELISA, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, Block, WB, FC, IP
Application: ELISA, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
