What does "Chimeric (Human-Mouse)" mean for this antibody?

This means the antibody is a recombinant protein that combines parts from both mouse and human antibodies. Typically, the variable domains (which bind the target, human TNF) are from a mouse antibody, while the constant domains (the "body" of the antibody) are from a human IgG1. This is a common research format, produced here in CHO cells.

What is the target of this antibody?

This antibody targets human TNF (Tumor Necrosis Factor), often called TNF-alpha. This is a pro-inflammatory cytokine that is a central mediator in inflammatory responses and is a major subject of research in immunology. This antibody is validated for functional studies (FuncS) related to this target.

Anti-Human TNF Recombinant Antibody (Infliximab)

CAT#: TAB-006

Recombinant monoclonal antibody to Human TNF. Infliximab (INN; trade name Remicade) is a monoclonal antibody against tumour necrosis factor alpha (TNF-α) used to treat autoimmune diseases.
Infliximab was approved for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis.

Gene Expression

Normal Tissue Figure 1 Tonsil

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF

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Specifications

Immunogen
rhTNF emulsified with complete Fraud`s adjuvant.

Host Species
Mouse

Derivation
Chimeric (mouse/human)

Type
IgG1 - kappa

Specificity
Tested positive against native human antigen

Species Reactivity
Human

Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, WB and most other immunological methods.

Trade name
Remicade, Remsima, Inflectra

CAS
170277-31-3

Generic Name
Infliximab

Biological Half-Life
9.5 days

ATC Code
L04AB02

DrugBank
DB00065

UNII
B72HH48FLU

ChEMBL
CHEMBL1201581

MW
144,190.3 g/mol

Related Disease
Ankylosing spondylitis (AS)

Product Property

Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.

Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

Alternative Names
Infliximab;Remicade, Remsima, Inflectra;170277-31-3;cA2;DB00065 TNF;tumor necrosis factor;TNFA, tumor necrosis factor (TNF superfamily, member 2);DIF;TNF superfamily;member 2;TNF alpha;TNFSF2;TNF-a;cachectin;APC1 protein;TNF, monocyte-derived;TNF, macroph

Gene ID
7124

UniProt ID
P01375

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Breast cancer biomarkers at key points during disease progression

Versatile TNF-alpha Antibody

This chimeric anti-TNF antibody (TAB-006) is a workhorse in our lab. We use it for functional studies (FuncS) to block TNF signaling, but it's also validated for WB, FC, and IF. It's a reliable chimeric IgG1 for studying the human TNF pathway.

Great for Multiple Assays

An excellent antibody for inflammation research. It's a CHO-expressed chimeric (Human-Mouse) IgG1. We've used it successfully for Immunoprecipitation (IP) and Immunofluorescence (IF). The fact that it's validated for such a broad range of applications is a major benefit.

Q&As

What does "Chimeric (Human-Mouse)" mean for this antibody?

A: This means the antibody is a recombinant protein that combines parts from both mouse and human antibodies. Typically, the variable domains (which bind the target, human TNF) are from a mouse antibody, while the constant domains (the "body" of the antibody) are from a human IgG1. This is a common research format, produced here in CHO cells.
What is the target of this antibody?

A: This antibody targets human TNF (Tumor Necrosis Factor), often called TNF-alpha. This is a pro-inflammatory cytokine that is a central mediator in inflammatory responses and is a major subject of research in immunology. This antibody is validated for functional studies (FuncS) related to this target.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-006, RRID: AB_3111734)

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Biosimilar Overview

Please refer to Infliximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Infliximab.

Related Diseases

Asthma

Inflammatory Bowel Diseases

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-006.pdf

MSDS

MSDS - TAB-006.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Infliximab"

Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human TNF. It is a monoclonal antibody against tumour necrosis factor alpha (TNF-α) used to treat autoimmune diseases.

DrugMonitor™ Anti-Infliximab Antibody (VS-1224-YC603)
Infliximab is a chimeric monoclonal IgG1 antibody targeting tumor necrosis factor-alpha (TNF-α), composed of human constant (75%) and murine variable (25%) regions, approved for intravenous treatment of various inflammatory disorders. The DrugMonitor™ Anti-Infliximab Antibody (VS-1224-YC603) is an anti-drug antibody (ADA) against Infliximab. This drug-based antibody is raised in mice immunized with the Infliximab. The anti-Infliximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Infliximab in samples.

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TAB-110CQ	Anti-Human TNF Recombinant Antibody (CDP571)	ELISA	Humanized antibody

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TAB-111CQ	Anti-Human TNF Recombinant Antibody (B5)	ELISA, WB	Human antibody

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TAB-115CQ	Human Anti-TNF Recombinant Antibody (TAB-115CQ)	ELISA, FC, Neut	Humanized antibody

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TAB-414CQ	Anti-Human TNF Single Domain Antibody (TAB-414CQ), Research Grade Biosimilar	ELISA, WB, Neut	Single domain antibody

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TAB-415CQ	Anti-Human TNF Single Domain Antibody (TAB-415CQ), Research Grade Biosimilar	ELISA, WB, Neut, FunS	Single domain antibody

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TAB-148CQ-S(P)	Anti-Human TNF Recombinant Antibody scFv Fragment	ELISA	Chimeric antibody (mouse/human)

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Gly-083LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated)	ELISA, FC	Human antibody
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Gly-085LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA, FC	Human antibody
Gly-085LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA, FC	Human antibody
Gly-163LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA	Chimeric antibody (mouse/human)
Gly-163LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA	Chimeric antibody (mouse/human)

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Gly-086LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA, FC	Human antibody
Gly-087LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA, FC	Human antibody

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Gly-088LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation)	ELISA, FC	Human antibody
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MOB-0229MZ	Recombinant Mouse Anti-Human TNF Antibody (clone G7C6)	ELISA, IHC	Mouse antibody

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NEUT-2051CQ	Mouse Anti-TNF Recombinant Antibody (clone CBL589)	ELISA, ICC, Neut	Mouse IgG1

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NEUT-2052CQ	Mouse Anti-TNF Recombinant Antibody (clone CBL570)	WB, Neut	Mouse IgG2b

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NEUT-2053CQ	Mouse Anti-TNF Recombinant Antibody (clone CBL571)	WB, Neut	Mouse IgG1

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NEUT-2054CQ	Rat Anti-Tnf Recombinant Antibody (NEUT-2054CQ)	Neut	Rat IgG1

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NEUT-2055CQ	Rat Anti-Tnf Recombinant Antibody (NEUT-2055CQ)	Neut, FC	Rat IgD

CAT	Product Name	Application	Type
NEUT-2057CQ	Rat Anti-Tnf Recombinant Antibody (NEUT-2057CQ)	Block, ELISA, IHC, WB	Rat IgG1

CAT	Product Name	Application	Type
NEUT-2070CQ	Mouse Anti-TNF Recombinant Antibody (clone 4F4)	Block, ELISA, ICC, IF, IHC, WB	Mouse IgG1

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NEUT-2071CQ	Rabbit Anti-TNF Recombinant Antibody (clone 6E10)	Block, ELISA, IHC, WB	Rabbit IgG1

CAT	Product Name	Application	Type
NEUT-2082CQ	Mouse Anti-TNF Recombinant Antibody (clone B-C7)	Block	Mouse IgG1

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MOR-3602	Rabbit Anti-Tnf Recombinant Antibody (clone DS3602AB)	ELISA, WB	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4460	Rabbit Anti-TNF Recombinant Antibody (clone SI554DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4461	Rabbit Anti-TNF Recombinant Antibody (clone SI555DS)	Neut	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4462	Rabbit Anti-TNF Recombinant Antibody (clone SI556DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4463	Rabbit Anti-TNF Recombinant Antibody (clone SI557DS)	FC	Rabbit IgG

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HPAB-0007-YC	Human Anti-TNF Recombinant Antibody (clone cA2)	ELISA, Neut	Chimeric (mouse/human) IgG1

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HPAB-0151-YC	Human Anti-TNF Recombinant Antibody (HPAB-0151-YC)	ELISA, Inhib, FuncS	Human IgG

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HPAB-0007-YC-S(P)	Human Anti-TNF Recombinant Antibody (clone cA2); scFv Fragment	ELISA, Neut	Mouse scFv

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HPAB-0151-YC-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0151-YC-S(P))	ELISA, Inhib, FuncS	Human scFv

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HPAB-0007-YC-F(E)	Human Anti-TNF Recombinant Antibody (clone cA2); Fab Fragment	ELISA, Neut	Human Fab

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HPAB-0151-YC-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0151-YC-F(E))	ELISA, Inhib, FuncS	Human Fab

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HPAB-0046-FY-S(P)	Mouse Anti-TNF Recombinant Antibody (clone 1B7); scFv Fragment	Neut	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0046-FY-F(E)	Mouse Anti-TNF Recombinant Antibody (clone 1B7); Fab Fragment	Neut	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0675-CN-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0675-CN-S(P))	ELISA, Neut	Human scFv

CAT	Product Name	Application	Type
HPAB-0675-CN-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0675-CN-F(E))	ELISA, Neut	Humanized Fab

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AFC-TAB-768	Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-768)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody

CAT	Product Name	Application	Type
AFC-TAB-006	Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
AFC-TAB-010	Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced	FC, IP, ELISA, Neut, FuncS	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY256	AbPlus™ Anti-TNF Magnetic Beads (4H31)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0724-YC1214	AbPlus™ Anti-TNF Magnetic Beads (VS-0724-YC1214)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY32	Human Anti-TNF (clone BPC1500) scFv-Fc Chimera	ELISA, Neut	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY215	CytoStream™ Mouse Anti-TNF Recombinant Antibody (clone MAb11)	FC	Mouse IgG1, kappa

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VS-0225-XY216	CytoStream™ Armenian Hamster Anti-TNF Recombinant Antibody (clone TN3-19.12)	ELISA, FC, Neut, IP, WB	Armenian Hamster IgG

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VS-0325-XY2313	Anti-TNF Immunohistochemistry Kit	IHC

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VS-0525-XY7348	Anti-Mouse TNF Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY7352	Anti-Human TNF Immunohistochemistry Kit	IHC

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VS-0525-XY7353	Anti-Rat TNF Immunohistochemistry Kit	IHC

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VS-0525-XY7355	Anti-Fish TNF Immunohistochemistry Kit	IHC

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