Recombinant Human Anti-human SCN9A Antibody
CAT#: MHH-891
Recombinant Human Antibody exhibits selective binding affinity to Human SCN9A, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-SCN9A mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-SCN9A mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane, actin filaments & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61843/1332_D6_5_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13679/30465_A_7_3_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13679/30465_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13679/30465_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13679/30465_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13679/30465_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13679/30465_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13679/30465_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, HHSteC, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169432-SCN9A/subcellular
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Specifications
- Immunogen
- Human sodium channel, voltage gated, type IX alpha subunit
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human sodium channel, voltage gated, type IX alpha subunit
- Species Reactivity
- Human
- Applications
- Formats of immunological tests: Western blot; Neutralization; Functional Study
Product Property
- Purity
- >95% by HPLC
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- SCN9A; sodium channel, voltage gated, type IX alpha subunit; PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; HSAN2D; Nav1.7; sodium channel protein type 9 subunit alpha; hNE-Na; peripheral sodium channel 1; neuroendocrine sodium channel; sodium channel prote
- Gene ID
- 6335
- UniProt ID
- Q15858
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-891-F(E) | Recombinant Anti-human SCN9A Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| MHH-891-F(E) | Recombinant Human Anti-human SCN9A Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-891-S(P) | Recombinant Anti-human SCN9A Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| MHH-891-S(P) | Recombinant Human Anti-human SCN9A Antibody scFv Fragment | WB, IHC, FuncS | scFv |
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| HPAB-0543-FY-S(P) | Human Anti-SCN9A Recombinant Antibody (clone 28608); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-0334CL-S(P) | Human Anti-SCN9A Recombinant Antibody; scFv Fragment (TAB-0334CL-S(P)) | FuncS, IHC, Block, Inhib, ELISA | Human scFv |
| TAB-0334CL-F(E) | Human Anti-SCN9A Recombinant Antibody; Fab Fragment (TAB-0334CL-F(E)) | FuncS, IHC, Block, Inhib, ELISA | Human Fab |
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| NS-053CN-F(E) | Mouse Anti-SCN9A Recombinant Antibody; Fab Fragment (NS-053CN-F(E)) | ELISA | Mouse Fab |
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