Anti-Hepatitis B virus antibody is a Human of Fab class that binds to an Hepatitis B virus. The humanized monoclonal antibody recognizes the preS1 domain of the human hepatitis B virus surface proteins with a broadly neutralizing activity in vivo.
Figure 1 Validation of epitope specificity with HzKR127-3.2.
GST-preS1 (amino acids 1–56) protein (WT) and a series of alanine replacement mutants were expressed in E. coli and subjected to 12% SDS-PAGE (bottom) followed by western blot analysis with KR127, HzKR127-3.1, or HzKR127-3.2 (Top). The protein band corresponding to the GST-preS1 is marked.
Figure 3 Affinity determination of murine and humanized KR127 antibody by a competitive ELISA.
A solution containing 3 ng of the purified antibody and various concentrations (1011–106 M) of the GST-preS1 protein as a competing antigen was preincubated at 37 jC for 3 h and added to each well that was coated with 0.1 Ag of the GST-preS1, then an indirect ELISA was done. Apparent affinity was determined as the reciprocal of the antigen concentration required to inhibit 50% maximal binding in the competitive ELISA.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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