Z-domain of protein A scaffold protein anti-Human PDGFRβ
CAT#: SZA-L236
This PDGFRβ specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=84 pM) for PDGFRβ as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28499/1774_C4_13_cr5950fa3646972_selected.jpg
Normal Tissue
Figure 2 Testis
Pachytene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Peritubular cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_4_6.jpg
Normal Tissue
Figure 3 Placenta
Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_2_7.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_B_9_5.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (ASC diff, ASC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113721-PDGFRB
❮
❯
Specifications
- Scaffold Name
- Z-domain of protein A
- Origin
- Staphylococcal protein A
- Core Structure
- 3-α helixes
- Variable Regions
- 13 Residues on first and second helix surface
- Target
- PDGFRβ
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 84 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for SZA-L236. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PDGFRB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0988CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0988CL) | ELISA | Human IgG |
| TAB-0988CL-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (TAB-0988CL-F(E)) | ELISA | Human Fab |
| TAB-0989CL-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (TAB-0989CL-F(E)) | ELISA | Human Fab |
| TAB-0990CL-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (TAB-0990CL-F(E)) | ELISA | Human Fab |
| TAB-0991CL-F(E) | Human Anti-PDGFRB Recombinant Antibody (TAB-0991CL-F(E)); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1850CQ | Recombinant Rat Anti-Pdgfrb Antibody (APB5) | FC, FuncS, Neut | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2638 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (DS2638AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0281CQ | Human Anti-PDGFRB Recombinant Antibody (clone 1B3) | ELISA, FC, WB, Neut | Human IgG |
| MRO-1193-CN | Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (CBACN-438) | WB, IHC, IP | Rabbit IgG |
| HPAB-S0105-YC | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11) | ELISA, Neut | Mouse IgG |
| HPAB-S0106-YC | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11) | ELISA, Neut | Humanized IgG |
| HPAB-S0107-YC | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22) | ELISA, Neut | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0281CQ-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); Fab Fragment | ELISA, FC, WB, Neut | Human Fab |
| HPAB-N0227-YC-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone PFH2); Fab Fragment | Block | Human Fab |
| HPAB-S0105-YC-F(E) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11); Fab Fragment | ELISA, Neut | Mouse Fab |
| HPAB-S0106-YC-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); Fab Fragment | ELISA, Neut | Humanized Fab |
| HPAB-S0107-YC-F(E) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); Fab Fragment | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-448CQ | Afuco™ Anti-PDGFRB Recombinant Antibody (AFC-TAB-448CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0227-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone PFH2); scFv Fragment | Block | Human scFv |
| HPAB-S0105-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-S0106-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); scFv Fragment | ELISA, Neut | Humanized scFv |
| HPAB-S0107-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-S0108-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22); scFv Fragment | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY209 | AbPlus™ Anti-PDGFRB Magnetic Beads (CBACN-438) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY27 | Human Anti-PDGFRB scFv-Fc Chimera (VS-0125-FY27) | Inhib | Human IgG1, scFv-Fc |
| VS-0325-FY47 | Human Anti-PDGFRB scFv-Fc Chimera (VS-0325-FY47) | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC884 | CytoStream™ Rabbit Anti-PDGFRB Recombinant Antibody (VS13-YC884) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1599 | Anti-PDGFRB Immunohistochemistry Kit | IHC | |
| VS-0525-XY5278 | Anti-Mouse PDGFRB Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC588 | Recombinant Anti-PDGFRB Vesicular Antibody, EV Displayed (VS-0425-YC588) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC143 | Recombinant Anti-PDGFRB (3rd domain x 4th domain) Biparatopic Antibody, Tandem scFv (Clone muM4TS.22 x Clone muM4TS.11) | ELISA, Neut | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA
Application: ELISA
Application: ELISA, Neut, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
