Anti-Mucin 16-vc-MMAE ADC

Name: Anti-Mucin 16-vc-MMAE ADC
SKU: ADC-123LZY
Rating: 5 (1 reviews)

CAT#: ADC-123LZY

This ADC product is composed of an anti-Mucin 16 antibody conjugated via vc linker to MMAE (anti-Mucin 16-vc-MMAE). It is in Phase I clinical trials and has demonstrated a response in Ovarian tumour treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Gene Expression

Normal Tissue Figure 1 Cervix

Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (A-431, HeLa)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16

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Specifications

Linker
VC (valine-citrulline)

Linker Class/Description
Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Drug
MMAE (monomethyl auristatin E)

Drug Class/Description
Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

Introduction
MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Alternative Names
MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

Gene ID
94025

UniProt ID
B3KY81

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Datasheet

Datasheet - ADC-123LZY.pdf

MSDS

MSDS - ADC-123LZY.pdf

COA

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