Rabbit Anti-ACVRL1 Recombinant Antibody (clone R07-5K6)
CAT#: VS3-XY3252
This product is a recombinant rabbit antibody that recognizes ACVRL1 (Activin A receptor like type 1). It specifically reacts with human, mouse and rat ACVRL1. This antibody has been reported for use in Western Blot and other applications.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong granular cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_7_3.jpg
Normal Tissue
Figure 4 Gallbladder
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_5_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139567-ACVRL1
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat ACVRL1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-5K6
- Applications
- WB
- Related Disease
- Telangiectasia; Hereditary Hemorrhagic
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1
- Gene ID
- 94
- UniProt ID
- P37023
- Long Name
- Activin A receptor like type 1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn98 (NX_P37023 [NX_P37023-1])
Modification sites at PhosphoSitePlus (P37023)
Glycosylation from GlyGen (P37023) 1 site
- Protein Refseq
- NP_000011.2; XP_047285857.1
- Function
- Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ACVRL1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3390z | Mouse Anti-ACVRL1 Recombinant Antibody (clone 39H9) | IHC, WB, FC | Mouse IgG2a |
| HPAB-0136-CN | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05444) | ELISA, IHC | Human IgG1 |
| HPAB-0137-CN | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05377) | ELISA, IHC | Human IgG1 |
| HPAB-J0024-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0024-YC) | ELISA, FC, WB | Human IgG1 |
| ZG-0528J | Rabbit Anti-ACVRL1 Recombinant Antibody (clone 8B6) | ELISA, WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0065 | Hi-Affi™ Rabbit Anti-ACVRL1 Recombinant Antibody (clone DS65AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-003ML | Anti-Human ACVRL1 Recombinant Antibody (TAB-003ML) | ELISA, IHC, FC, IP, IF, Inhib | IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-003ML | Afuco™ Anti-ACVRL1 ADCC Recombinant Antibody, ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0024-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0024-YC-S(P)) | ELISA, FC, WB | Human scFv |
| HPAB-J0025-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0025-YC-S(P)) | ELISA, FC, WB | Human scFv |
| HPAB-J0026-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0026-YC-S(P)) | ELISA, FC, WB, Inhib, FuncS | Human scFv |
| HPAB-J0027-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0027-YC-S(P)) | ELISA | Human scFv |
| HPAB-J0028-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0028-YC-S(P)) | ELISA, FC, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0024-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0024-YC-F(E)) | ELISA, FC, WB | Human Fab |
| HPAB-J0025-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0025-YC-F(E)) | ELISA, FC, WB | Human Fab |
| HPAB-J0026-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0026-YC-F(E)) | ELISA, FC, WB, Inhib, FuncS | Human Fab |
| HPAB-J0027-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0027-YC-F(E)) | ELISA | Human Fab |
| HPAB-J0028-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0028-YC-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1261 | AbPlus™ Anti-ACVRL1 Magnetic Beads (VS-0724-YC1261) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY91 | Human Anti-ACVRL1 (clone MOR05377) scFv-Fc Chimera | ELISA, IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC491 | Recombinant Anti-ACVRL1 Vesicular Antibody, EV Displayed (VS-0425-YC491) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY141 | Anti-ACVRL1 Immunohistochemistry Kit | IHC |
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