Human Anti-ACVRL1 (clone MOR05377) scFv-Fc Chimera (CAT#: VS-0325-FY91)
MOR05377 is a fully human, high-affinity antibody specific for ALK1. The anti-ALK1 scFv-Fc antibody targets Activin Receptor-like Kinase 1 (ALK1), a receptor involved in angiogenesis and vascular development. It is being explored for its potential to inhibit ALK1 signaling, which may have therapeutic benefits in treating fibrosis and certain cancers. The scFv-Fc format enhances its bioavailability and stability, making it suitable for prolonged therapeutic use.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong granular cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong granular cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/ihc_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_7_3.jpg
Figure 4 Gallbladder
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_5_4.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_5_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_8_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_8_5.jpg
Figure 6 Testis
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_6_6.jpg
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_6_6.jpg
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_9_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139567-ACVRL1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139567-ACVRL1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- MOR05377 specifically binds to human ALK1 and murine (mouse) ALK1.
- Species Reactivity
- Human, Mouse
- Clone
- MOR05377
- Applications
- ELISA, Immunohistochemistry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Activin A Receptor Like Type 1; TGF-B Superfamily Receptor Type I; Activin A Receptor Type II-Like 1; Activin A Receptor Type IL; EC 2.7.11.30; ACVRLK1; TSR-I; ALK-1; ALK1
- Gene ID
- 94
- UniProt ID
- P37023
- Long Name
- Activin A Receptor Like Type 1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn98
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Protein Refseq
- NP_000011.2; XP_047285857.1
- Function
- Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3390z | Mouse Anti-ACVRL1 Recombinant Antibody (clone 39H9) | IHC, WB, FC | Mouse IgG2a |
| HPAB-0136-CN | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05444) | ELISA, IHC | Human IgG1 |
| HPAB-0137-CN | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05377) | ELISA, IHC | Human IgG1 |
| HPAB-J0029-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0029-YC) | ELISA, FC, WB | Human IgG |
| VS3-XY3252 | Rabbit Anti-ACVRL1 Recombinant Antibody (clone R07-5K6) | WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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