Mouse Anti-ANGPT2 Recombinant Antibody (clone 10D6) (CAT#: HPAB-0172-WJ)

This product is a mouse antibody targeting human ANG2. This antibody can be used in the method of potentiating immunity or preventing and/or treating an immune-related disease.

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ELISA

Figure 1 Results of Ang2-Tie2 competition ELISA showing the Ang2-Tie2 binding inhibition level depending on the concentration of an anti-Ang2 antibody.

Figure 1 Results of Ang2-Tie2 competition ELISA showing the Ang2-Tie2 binding inhibition level depending on the concentration of an anti-Ang2 antibody.

IB

Figure 2 Results of immunoblotting showing the change in the level of Tie2 receptor and phosphorylated Tie2 receptor depending on the concentration of an anti-Ang2 antibody.

Figure 2 Results of immunoblotting showing the change in the level of Tie2 receptor and phosphorylated Tie2 receptor depending on the concentration of an anti-Ang2 antibody.

IB

Figure 3 Results of immunoblotting showing the change in the level of Tie2 receptor and phosphorylated Tie2 receptor by an anti-Ang2 antibody compared to that of a control antibody (RG).

Figure 3 Results of immunoblotting showing the change in the level of Tie2 receptor and phosphorylated Tie2 receptor by an anti-Ang2 antibody compared to that of a control antibody (RG).

FuncS

Figure 4 A graph showing the ratio of phosphorylated Tyr in Tie2 receptor.

Figure 4 A graph showing the ratio of phosphorylated Tyr in Tie2 receptor.

IB

Figure 5 Results of immunoblotting showing the phosphorylation level of proteins relating to downstream signaling of Tie2 receptor by treatment of an anti-Ang2 antibody.

Figure 5 Results of immunoblotting showing the phosphorylation level of proteins relating to downstream signaling of Tie2 receptor by treatment of an anti-Ang2 antibody.

IB

Figure 6 Results of immunoblotting showing the phosphorylation level of Tie2 receptor and Akt relating to downstream signaling of Tie2 receptor by treatment of an anti-Ang2 antibody in an animal model.

Figure 6 Results of immunoblotting showing the phosphorylation level of Tie2 receptor and Akt relating to downstream signaling of Tie2 receptor by treatment of an anti-Ang2 antibody in an animal model.

Figure 7 The degree of binding between an anti-Ang2 antibody and Ang2.

Figure 7 The degree of binding between an anti-Ang2 antibody and Ang2.

FuncS

Figure 8 The phosphorylation level of Akt relating to downstream signaling of Tie2 receptor by treatment of a humanized and affinity-matured anti-Ang2 antibody together with Ang2.

Figure 8 The phosphorylation level of Akt relating to downstream signaling of Tie2 receptor by treatment of a humanized and affinity-matured anti-Ang2 antibody together with Ang2.

FuncS

Figure 9 The inhibition of cancer cell (MKN45) growth by treatment with an anti-c-Met/anti-Ang2 bispecific antibody.

Figure 9 The inhibition of cancer cell (MKN45) growth by treatment with an anti-c-Met/anti-Ang2 bispecific antibody.

FuncS

Figure 10 The inhibition of cancer cell (EBC1) growth by treatment with an anti-c-Met/anti-Ang2 bispecific antibody.

Figure 10 The inhibition of cancer cell (EBC1) growth by treatment with an anti-c-Met/anti-Ang2 bispecific antibody.


Specifications

  • Immunogen
  • Human Ang2 protein
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1, κ
  • Specificity
  • Human ANG2
  • Species Reactivity
  • Human
  • Clone
  • 10D6
  • Applications
  • ELISA, IB, FuncS
  • Related Disease
  • Immune-related disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Immunoblotting and Functional Assay.

Target

  • Alternative Names
  • ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 10D6"

See other products for "ANGPT2"

Single-domain Antibody

CAT Product Name Application Type
NABL-070 Recombinant Anti-human ANGPT2 VHH Single Domain Antibody WB, IHC, FC, FuncS Llama VHH
TAB-0032CL-VHH Anti-Human ANGPT2 VHH Single Domain Antibody ELISA, Block, SPR Single domain antibody
TAB-0035CL-VHH Anti-Human ANGPT2 VHH Single Domain Antibody ELISA, Block, SPR Single domain antibody

Recombinant Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0170 Hi-Affi™ Rabbit Anti-ANGPT2 Recombinant Antibody (clone DS170AB) IHC-Fr, WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-461CQ Afuco™ Anti-ANGPT2 Recombinant Antibody (AFC-TAB-461CQ), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib Human IgG1, κ

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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