Human Anti-CALCRL Recombinant Antibody; Fab Fragment (HPAB-AP021-YC-F(E)) (CAT#: HPAB-AP021-YC-F(E))
This product is a recombinant Human antibody Fab Fragment that recognizes CALCRL. The antibody was purified by affinity chromatography.
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Custom Production
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Subcellular Location and Protein Expression
Normal Tissue
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1057_C8_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1057_C8_1_selected.jpg
Figure 2 IHC staining of human skin
(Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/ihc_selected.jpg
(Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/ihc_selected.jpg
Figure 3 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1595_A10_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1595_A10_2_blue_red_green.jpg
Figure 4 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_7_5.jpg
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_7_5.jpg
Figure 5 Colon
(Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_3.jpg
(Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_3.jpg
Figure 6 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_5.jpg
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_5.jpg
Figure 7 Testis
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_6_6.jpg
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_6_6.jpg
Figure 8 Skin
(Fibroblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Langerhans
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_8_1.jpg
(Fibroblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Langerhans
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_8_1.jpg
Specifications
- Immunogen
- Purified soluble CGRP receptor protein and purified CGRP R membranes prepared from AM-I CHO cells stably expressing CGRP R
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human CALCRL
- Species Reactivity
- Human, Cynomolgus
- Applications
- FC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Calcitonin Receptor Like Receptor; Calcitonin Receptor-Like; CGRP Type 1 Receptor; CGRPR; Calcitonin Gene-Related Peptide Type 1 Receptor; Calcitonin Receptor-Like Receptor; CRLR
- Gene ID
- 10203
- UniProt ID
- Q16602
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-338-VHH | Recombinant Anti-Human CALCRL VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
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