Mouse Anti-Cardiolipin Recombinant Antibody (clone A1.72) (CAT#: FAMAB-0251JF)
Recombinant monoclonal antibody specially binds to cardiolipin. This mouse anti-cardiolipin antibody (A1.72) can be potencially used in the treatment of patients with systemic lupus erythematosus and other autoimmune disorders.
Specific Inquiry
ELISA
Figure 1 Anti-cardiolipin autoantibodies were affinity-purified from patient serum by cardiolipin liposome affinity chromatography.
Bars represent standard errors.
Chamley, L. W., Duncalf, A. M., Konarkowska, B., Mitchell, M. D., & Johnson, P. M. (1999). Conformationally altered β2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. Clinical and experimental immunology, 115(3), 571.
WB
Figure 2 β2-glycoprotein I (b2-GPI) was electrophoresed on an 8% SDS–PAGE gel, transferred to a nitrocellulose membrane and probed with anti-cardiolipin autoantibody.
All results are representative of at least four independent experiments.
Chamley, L. W., Duncalf, A. M., Konarkowska, B., Mitchell, M. D., & Johnson, P. M. (1999). Conformationally altered β2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. Clinical and experimental immunology, 115(3), 571.
IHC
Figure 3 Immunohistochemical staining of 4-HNE-protein adducts in tumor and adjacent non-cancerous tissue from difffferent stage HCC patients.
The experiments were performed in a double-blinded fashion.
Zhong, H., Xiao, M., Zarkovic, K., Zhu, M., Sa, R., Lu, J., ... & Waeg, G. (2017). Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer. Free Radical Biology and Medicine, 102, 67-76.
Specifications
- Host Species
- Mouse
- Derivation
- Mouse phage display scFv library
- Type
- Mouse IgG
- Specificity
- Cardiolipin
- Clone
- A1.72
- Applications
- WB, ELISA, IHC
- Related Disease
- Systemic lupus erythematosus, other autoimmune disorders
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The Cardiolipin antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
- Alternative Names
- 1,3-bis(sn-3'-phosphatidyl)-sn-glycerol; Cardiolipin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0251JF-F(E) | Mouse Anti-Cardiolipin Recombinant Antibody (clone A1.72); Fab Fragment | IB, ELISA, FuncS | Mouse Fab |
| FAMAB-0252JF-F(E) | Mouse Anti-Cardiolipin Recombinant Antibody (clone A1.84); Fab Fragment | IB, ELISA, FuncS | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0251JF-S(P) | Mouse Anti-Cardiolipin Recombinant Antibody (clone A1.72); scFv Fragment | IB, ELISA, FuncS | Mouse scFv |
| FAMAB-0252JF-S(P) | Mouse Anti-Cardiolipin Recombinant Antibody (clone A1.84); scFv Fragment | IB, ELISA, FuncS | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0252JF | Mouse Anti-Cardiolipin Recombinant Antibody (clone A1.84) | WB, ELISA, IHC | Mouse IgG |
| FAMAB-0458WJ | Human Anti-Cardiolipin Recombinant Antibody (clone RSP4) | ELISA, WB | Human IgM, λ |
| FAMAB-0459WJ | Human Anti-Cardiolipin Recombinant Antibody (clone IS4) | ELISA, WB | Human IgG |
| FAMAB-0460WJ | Human Anti-Cardiolipin Recombinant Antibody (clone B3) | ELISA, WB | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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