Rabbit Anti-CASP8 Recombinant Antibody (VS13-YC132)
CAT#: VS13-YC132
The Rabbit Anti-CASP8 Recombinant Antibody is specific for human CASP8. CASP8 plays a pivotal role in apoptosis, responding to stimuli via the FADD domain and interactions indicative of broader neurodegenerative disease involvement, with spliced variant complexity. The anti-CASP8 antibody can be used for Western blot (1/1000-1/2000), Immunocytochemistry (1/50-1/200), Immunofluorescence (1/50-1/200), Immunohistochemistry-paraffin (1/50-1/200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/69_H9_2_selected.jpg
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Specifications
- Immunogen
- Recombinant human Caspase-8, aa 200-249.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CASP8
- Species Reactivity
- Human
- Applications
- WB, ICC, IF, IHC-P
- Conjugate
- NONE
- Related Disease
- Huntington disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/2000
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Target
- Alternative Names
- Caspase 8; Caspase 8, Apoptosis-Related Cysteine Peptidase; Caspase 8, Apoptosis-Related Cysteine Protease; MORT1-Associated Ced-3 Homolog; ICE-Like Apoptotic Protease 5; Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; FADD-Like ICE; Casp-8; FLICE; CAP4;
- Gene ID
- 841
- UniProt ID
- Q14790
- Long Name
- Caspase 8
- Sequence Similarities
- Belongs to the peptidase C14A family.
- Cellular Localization
- Nucleus; Cytoplasm; Cell projection
- Protein Refseq
- XP_005246950.1; XP_011510271.1; XP_047301915.1; XP_047301916.1; XP_047301917.1
- Function
- Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood.
Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death.
Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10.
Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A.
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CASP8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0330CT | Mouse Anti-CASP8 Recombinant Antibody (clone 1H11) | WB | Mouse IgG1 |
| ZG-0072J | Mouse Anti-CASP8 Recombinant Antibody (clone 2G12) | WB, IF, ICC, IHC-P | Mouse IgG |
| ZG-0833F | Mouse Anti-CASP8 Recombinant Antibody (clone FLICE 1 1-37) | WB | Mouse IgG |
| ZG-0834F | Mouse Anti-CASP8 Recombinant Antibody (clone FLICE 3) | WB | Mouse IgG |
| VS7-HM297 | Mouse Anti-CASP8 Recombinant Antibody (clone CBL097HM) | WB, IHC-p, IF, FCM, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0082MZ | Chicken Anti-Caspase 8 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0479 | Hi-Affi™ Rabbit Anti-CASP8 Recombinant Antibody (clone DS479AB) | FC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY321 | Anti-CASP8 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1009 | Anti-Mouse CASP8 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1012 | Anti-Human CASP8 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1010 | Anti-Monkey CASP8 Immunohistochemistry Kit | IHC |
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