Anti-CASP8 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, your professional partner in the field of immunology and cancer biology, is offering you highly specific anti-CASP8 recombinant antibodies. Caspase-8 (CASP8) is an initiator caspase of the extrinsic pathway of apoptosis, which is considered a primary link between cell surface death receptors and the execution machinery of cell suicide. High-quality antibodies for this enzyme are crucial for studying TNF family signaling, immune surveillance, and chemoresistance mechanisms.

CASP8: The Initiator of Death Receptor Signaling

Caspase-8 (CASP8) is an initiator cysteine protease, which is involved in the extrinsic pathway of apoptosis. It is recruited to the Death-Inducing Signaling Complex (DISC) through its death effector domains (DEDs). DISC is assembled on the cytoplasmic side of cell surface death receptors (Fas or TRAIL receptors) upon ligand binding. The recruitment of multiple pro-caspase-8 molecules to DISC brings them in close proximity, resulting in their dimerization and auto-activation. Active caspase-8 subsequently initiates the apoptotic signaling cascade by direct cleavage and activation of downstream executioner caspases (e.g., caspase-3). Caspase-8 can also cleave the protein Bid and link to the intrinsic mitochondrial pathway of apoptosis.

Alternative Names

CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease

Background

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Anti-CASP8 rAb Products

The anti-CASP8 recombinant antibodies provided by Creative Biolabs are designed to exhibit the highest specificity and performance. We have antibodies that detect the full-length pro-form as well as antibodies that are specific for the cleaved, active fragments of caspase-8. These are the ultimate tools to monitor activation of the extrinsic pathway of apoptosis by Western Blot.

Table 1. Featured anti-CASP8 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Scientific integrity is our top priority. The production of our anti-CASP8 recombinant antibodies is subject to the most stringent quality control criteria. Each antibody lot is extensively tested for its purity, specificity and consistency in performance, which means that you can trust our antibodies to detect caspase-8 cleavage in response to death receptor ligation.

Customer Reviews

rAb Production

Creative Biolabs’ leading-edge antibody production platforms are tailored to the needs of a specialist field such as immunology and cancer. Our anti-cleaved CASP8 recombinant antibodies are carefully selected to only recognize the activated enzyme and thus provide you with the highest possible specificity for your experiments.

Featured Anti-CASP8 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CASP8 recombinant antibody production.

Fig.4 Gram-scale anti-CASP8 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating scientific innovation with flexible antibody solutions. Our anti-CASP8 recombinant antibodies are available in different formats to meet the needs of any experiment, helping researchers from around the world to study this key initiator caspase.

Fig.5 Full-length anti-CASP8 recombinant antibody production and modalities.

Probe into extrinsic apoptosis with the high specificity of Creative Biolabs’ anti-CASP8 recombinant antibodies. Benefit from the stringent validation and consistency of our portfolio for your investigation of this important pathway in cancer and immunology. Place your trust in our experience for a reliable foundation for your studies. Get in touch with our scientific team today.