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  • Afuco™ Anti-CD248 ADCC Recombinant Antibody (Ontuxizumab), ADCC Enhanced

Afuco™ Anti-CD248 ADCC Recombinant Antibody (Ontuxizumab), ADCC Enhanced (CAT#: AFC-TAB-773)

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant chimeric/humanized hybrid (mouse/human) antibody expressed in CHO binding to human CD248. Ontuxizumab is a monoclonal antibody designed for the treatment of cancer.


See more Engineered Antibody products for Cd248
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line ASC TERT1
Figure 1 IF staining of human cell line ASC TERT1
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1774_B3_8_cr5950f83255423_selected.jpg
Figure 2 IF staining of human cell line BJ
Figure 2 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1368_F10_1_blue_red_green.jpg
Figure 3 IF staining of human cell line Hep G2
Figure 3 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1293_C11_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_B_9_5.jpg
Figure 5 Colon
Figure 5 Colon
(Goblet cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_A_9_3.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ, BJ hTERT+, fHDF/TERT166, HSkMC, U-2197)
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ, BJ hTERT+, fHDF/TERT166, HSkMC, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174807-CD248

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Chimeric
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Clone
  • Ontuxizumab
  • Applications
  • Neut, ELISA, IF, IP, FuncS, FC
  • Conjugate
  • Unconjugated
  • Generic Name
  • Ontuxizumab
  • Related Disease
  • Solid tumors

Product Property

  • Purity
  • >95% by SDS-PAGE
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Ontuxizumab; 946415-62-9; MORAb-004; CD248; CD248 molecule, endosialin; CD164 sialomucin like 1, CD164L1, CD248 antigen, endosialin; endosialin; TEM1; tumor endothelial marker 1; 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; CD164L1; MGC119478;

Related Resources

  • Biosimilar Overview
Please refer to Ontuxizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ontuxizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ontuxizumab"

Anti-CD248 Recombinant Antibody (Ontuxizumab)
Recombinant chimeric/humanized hybrid (mouse/human) antibody expressed in CHO binding to human CD248. Ontuxizumab is a monoclonal antibody designed for the treatment of cancer.

See other products for "Cd248"

Single-domain Antibody

CAT Product Name Application Type
NAB-289-sdAb Recombinant Anti-Mouse Cd248 VHH Single Domain Antibody WB, ICC, ChiP, FA, ELISA Llama VHH

Chimeric Antibody

CAT Product Name Application Type
TAB-773 Anti-CD248 Recombinant Antibody (Ontuxizumab) Neut, ELISA, IF, IP, FuncS, FC, ICC IgG1 - kappa

Recombinant Antibody

CAT Product Name Application Type
MOB-2375z Mouse Anti-CD248 Recombinant Antibody (clone 5B2) WB, ELISA, IHC Mouse IgG1
HPAB-AP032-YC Human Anti-CD248 Recombinant Antibody (HPAB-AP032-YC) ELISA, FC, WB, FuncS Human IgG
VS-0723-CJ8 Human Anti-CD248 Recombinant Antibody (clone 78) ELISA, FC, IF Human IgG

Humanized Antibody

CAT Product Name Application Type
TAB-114CL Humanized Anti-Human CD248 Recombinant Antibody ELISA Antibody

Human Antibody

CAT Product Name Application Type
TAB-340MZ Human Anti-CD248 Recombinant Antibody (TAB-340MZ) ELISA, FC Human IgG
TAB-340MZ-S(P) Human Anti-CD248 Recombinant Antibody; scFv Fragment (TAB-340MZ-S(P)) ELISA, FC Human scFv
TAB-340MZ-F(E) Human Anti-CD248 Recombinant Antibody; Fab Fragment (TAB-340MZ-F(E)) ELISA, FC Human Fab

Mouse Antibody

CAT Product Name Application Type
TAB-341MZ Anti-Human CD248 Recombinant Antibody (FB5) IHC
TAB-341MZ-S(P) Anti-Human CD248 Recombinant Antibody scFv Fragment (FB5) IHC
TAB-341MZ-F(E) Anti-Human CD248 Recombinant Antibody Fab Fragment (FB5) IHC

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN0505 PE-A*02:01/Human CD248 (LLVPTCVFLV) MHC Tetramer FCM, IHC
MHC-CN0506 APC-A*02:01/Human CD248 (LLVPTCVFLV) MHC Tetramer FCM, IHC
MHC-CN0507 FITC-A*02:01/Human CD248 (LLVPTCVFLV) MHC Tetramer FCM, IHC
MHC-CN0508 A*02:01/Human CD248 (LLVPTCVFLV) MHC Tetramer FCM, IHC
MHC-YF742 A*02:01/Human TEM1 (LLVPTCVFLV) MHC Pentamer FCM

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-AP032-YC-S(P) Human Anti-CD248 Recombinant Antibody; scFv Fragment (HPAB-AP032-YC-S(P)) ELISA, FC, WB, FuncS Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-AP032-YC-F(E) Human Anti-CD248 Recombinant Antibody; Fab Fragment (HPAB-AP032-YC-F(E)) ELISA, FC, WB, FuncS Human Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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