Anti-CD38 Antibody-Cytokine Fusion Protein, IgG (VS0624W3)-IFNα2b
CAT#: VS-0624-FY89
Human IFNα-2b is a protein renowned for its potent anticancer properties. Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules. Modakafusp alfa can be used in the research of multiple myeloma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/1126_F5_3_selected.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/51753_A_9_3.jpg
Normal Tissue
Figure 3 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/51753_A_1_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/51753_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, MOLT-4, REH, RPMI-8226, U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004468-CD38
❮
❯
Specifications
- Target
- CD38
- Molecule Class
- IgG-IFNα2b
- Species Reactivity
- Human
- Clone
- VS0624W3
- Related Disease
- Cancers; autoimmune and inflammatory diseases
- Cytokine 1
- IFNα2b
- Cytokines 1 Description
- Human interferon alpha-2 (IFNα2) is a cytokine that belongs to the type I interferon family. IFNα2 is a protein secreted by virus-infected cells and acts on other cells to inhibit viral infection. IFNα2a and IFNα2b are better known by their trade names Roferon-A and Intron A. Upstream of the coding sequence is the promoter region, which contains sequences that regulate the transcription of the IFNA2 gene into messenger RNA (mRNA). The amino acid sequences of IFNα2a and IFNα2b differ only at position 23 (lysine in IFNα2a, arginine in IFNα2b).
- Cytokine 1 Species
- Human
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Richter's Syndrome and Leukemia, Chronic Lymphocytic. Among its related pathways are Cell-type Dependent Selectivity of CCK2R Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.
- Alternative Names
- CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase; TAK-573; Modakafusp alfa
- Gene ID
- 952
- UniProt ID
- P28907
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0624-FY89. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CD38"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-079 | Recombinant Anti-Human CD38 VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| HPAB-0625-CN | Recombinant Bactrian camel Anti-CD38 Single Domain Antibody (HPAB-0625-CN) | ELISA | VHH |
| HPAB-0626-CN | Recombinant Bactrian camel Anti-CD38 Single Domain Antibody (HPAB-0626-CN) | ELISA | VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-151LC | Mouse Anti-CD38 Recombinant Antibody (TAB-151LC) | ELISA | Mouse IgG, κ |
| TAB-151LC-S(P) | Mouse Anti-CD38 Recombinant Antibody; scFv Fragment (TAB-151LC-S(P)) | ELISA | Mouse scFv |
| TAB-151LC-F(E) | Mouse Anti-CD38 Recombinant Antibody; Fab Fragment (TAB-151LC-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-152LC-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (TAB-152LC-S(P)) | FC | Human scFv |
| TAB-153LC-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (TAB-153LC-S(P)) | ELISA, FC | Human scFv |
| TAB-154LC-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (TAB-154LC-S(P)) | ELISA, FC | Human scFv |
| TAB-155LC-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (TAB-155LC-S(P)) | ELISA, FC | Human scFv |
| TAB-156LC-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (TAB-156LC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-349CQ | Rat Anti-CD38 Recombinant Antibody (clone NIMR-5) | Neut, FC, IHC-Fr, IP, BA | Rat IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0556 | Hi-Affi™ Rabbit Anti-CD38 Recombinant Antibody (clone DS556AB) | FC, ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0300-YC-F(E) | Human Anti-CD38 Recombinant Antibody; Fab Fragment (HPAB-0300-YC-F(E)) | Cyt | Human Fab |
| HPAB-0301-YC-F(E) | Human Anti-CD38 Recombinant Antibody; Fab Fragment (HPAB-0301-YC-F(E)) | ELISA, FC, Cyt | Human Fab |
| HPAB-0302-YC-F(E) | Human Anti-CD38 Recombinant Antibody; Fab Fragment (HPAB-0302-YC-F(E)) | FuncS | Humanized Fab |
| FAMAB-0046CQ-F(E) | Mouse Anti-CD38 Recombinant Antibody (clone AT13/5); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0134CQ-F(E) | Human Anti-CD38 Recombinant Antibody; Fab Fragment (HPAB-0134CQ-F(E)) | ELISA, FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1357LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1357LY-S(P)) | ELISA | Human scfv |
| HPAB-1358LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1358LY-S(P)) | ELISA | Human scfv |
| HPAB-1359LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1359LY-S(P)) | ELISA | Human scfv |
| HPAB-1360LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1360LY-S(P)) | ELISA | Human scfv |
| HPAB-1361LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1361LY-S(P)) | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0467LY | Mouse Anti-CD38 Recombinant Antibody (clone S5B8) | ELISA, Block | Mouse IgG |
| HPAB-0468LY | Mouse Anti-CD38 Recombinant Antibody (clone S5A10) | ELISA, Block | Mouse IgG |
| HPAB-0469LY | Mouse Anti-CD38 Recombinant Antibody (clone S5B7) | ELISA, Block | Mouse IgG |
| HPAB-0470LY | Mouse Anti-CD38 Recombinant Antibody (clone S5B5) | ELISA, Block | Mouse IgG |
| HPAB-0471LY | Mouse Anti-CD38 Recombinant Antibody (clone S5D3) | ELISA, Block | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC775 | AbPlus™ Anti-CD38 Magnetic Beads (VS-0724-YC775) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY44 | CytoStream™ Mouse Anti-CD38 Recombinant Antibody (clone 14.27) | FC | Mouse IgG2b, kappa |
| VS-0225-XY45 | CytoStream™ Mouse Anti-CD38 Recombinant Antibody (clone HIT2) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY60 | Human Anti-CD38 (clone OKT10) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY363 | Anti-CD38 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1168 | Anti-Mouse CD38 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1167 | Anti-Human CD38 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC12 | Recombinant Anti-CD38 Biparatopic Antibody, Asymmetric sdAb-Fab | ELISA, Inhib | Asymmetric sdAb-Fab |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: Neut, FC
-3.jpg)
Application: Neut
Application: ELISA, Inhib, FuncS
Application: ELISA, IHC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
