Anti-CDH1 (clone hSC10.17) Recombinant Antibody Coupled Liposome (VS-1024-FY171)
CAT#: VS-1024-FY171
These specialized liposomes are designed to target CDH1, also known as E-cadherin, a protein commonly expressed on the surface of melanoma cells. By selectively binding to this molecule, the liposomes can enhance the precision of drug delivery, ensuring that the therapeutic agents are concentrated where they are most needed, thereby increasing their effectiveness. Furthermore, by interfering with cell adhesion signaling pathways, these liposomes may disrupt the tumor's ability to invade surrounding tissues, potentially leading to reduced metastasis and improved patient outcomes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane, the Golgi apparatus & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28364/672_E7_2_selected.jpg
Normal Tissue
Figure 2 ParaThyroid gland
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4812/158154_A_3_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Bowman's capsule Staining: Medium Intensity: Moderate Quantity:>75% Collecting ducts Staining: High Intensity: Strong Quantity:>75% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_7_5.jpg
Normal Tissue
Figure 1 Urinary bladder
Urothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_5_5.jpg
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BEWO, CACO-2, CAPAN-2, HaCaT, hTCEpi, MCF7, OE19, RT4, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000039068-CDH1
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- hSC10.17
- Antibody Type
- IgG1
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that has been specifically formulated to bind to CDH1, the gene encoding E-cadherin, which is crucial for maintaining cell-cell adhesion in epithelial tissues. The precision of this antibody allows researchers to investigate the role of E-cadherin in cancer progression and metastasis, particularly its function in tumor microenvironments. By focusing on CDH1, this tool can enhance our understanding of the molecular mechanisms that govern cellular integrity and communication within tissues.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CDH1
- Introduction
- This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
- Alternative Names
- Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO
- Full Name
- Cadherin 1
- Gene ID
- 999
- UniProt ID
- P12830
- Cellular Localization
- Cell junction, Cell membrane, Endosome, Golgi apparatus, Membrane
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY171. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone hSC10.17"
- CAT
- Product Name
See other products for "CDH1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1411CL | Anti-Human CDH1 Recombinant Antibody (hSC10.17) | Cyt, FuncS, Inhib | Humanized antibody |
| TAB-1411CL-S(P) | Anti-Human CDH1 Recombinant Antibody scFv Fragment (hSC10.17) | ELISA | Humanized antibody |
| TAB-1411CL-F(E) | Anti-Human CDH1 Recombinant Antibody Fab Fragment (hSC10.17) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0111MZ | Chicken Anti-CDH1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-440CQ | Rat Anti-CDH1 Recombinant Antibody (clone DECMA-1) | FC, FuncS, Neut, WB, IF, IP | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-441CQ | Rat Anti-Cdh1 Recombinant Antibody (NEUT-441CQ) | IHC-Fr, Block, ICC, IF, WB | Rat IgG1 |
| NEUT-442CQ | Mouse Anti-CDH1 Recombinant Antibody (VMC173) | ELISA, FC, ICC, IF, IHC, IP, WB, IHC-P, IHC-Fr, Block | Mouse IgG1 |
| NEUT-443CQ | Mouse Anti-CDH1 Recombinant Antibody (VMC174) | ELISA, IP, WB, ICC, Block, FC, IHC-P | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0611 | Hi-Affi™ Rabbit Anti-CDH1 Recombinant Antibody (clone DS611AB) | ICC, IF, IHC-P, IHC-P, IP, WB | Rabbit IgG |
| MOR-4569 | Hi-Affi™ Rabbit Anti-CDH1 Recombinant Antibody (clone TH81DS) | WB, IF, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0506-CN | Rabbit Anti-CDH1 Recombinant Antibody (clone CBACN-205) | WB, IF, IHC, IP, FC | Rabbit IgG |
| MRO-0514-CN | Mouse Anti-CDH1 Recombinant Antibody (clone 3-F9) | WB, IF, IHC, FC | Mouse IgG2b |
| MRO-0515-CN | Mouse Anti-CDH1 Recombinant Antibody (clone A0-G11) | WB, IF, IHC, FC | Mouse IgG1 |
| MRO-1830-CN | Rabbit Anti-CDH1 Polyclonal Antibody (MRO-1830-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MOB-242YJL | Rabbit Anti-CDH1 Recombinant Antibody (clone CBC226) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0464-WJ-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.6); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0465-WJ-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.15); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0466-WJ-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.17); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0467-WJ-F(E) | Human Anti-CDH1 Recombinant Antibody (clone hSC10.17); Fab Fragment | ELISA, FC | Humanized Fab |
| PABJ-0035-F(E) | Mouse Anti-CDH1 Recombinant Antibody Fab Fragment (PABJ-0035-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0464-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.6); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0465-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.15); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0466-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.17); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0467-WJ-S(P) | Human Anti-CDH1 Recombinant Antibody (clone hSC10.17); scFv Fragment | ELISA, FC | Humanized scFv |
| PABJ-0035-S(P) | Mouse Anti-CDH1 Recombinant Antibody scFv Fragment (PABJ-0035-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1204 | AbPlus™ Anti-CDH1 Magnetic Beads (VS-0724-YC1204) | IP, Protein Purification | |
| VS-0724-YC1271 | AbPlus™ Anti-Cdh1 Magnetic Beads (VS-0724-YC1271) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC191 | CytoStream™ Rabbit Anti-CDH1 Recombinant Antibody (VS13-YC191) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC562 | Recombinant Anti-CDH1 Vesicular Antibody, EV Displayed (VS-0425-YC562) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1278 | Anti-CDH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1279 | Anti-Mouse CDH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1281 | Anti-Bovine CDH1 Immunohistochemistry Kit | IHC |
See Our Custom Production in Action
Popular Products
Application: FC, Cyt, Stim, PP, Agonist
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
-2.png)
Application: IB, ELISA, FC, FuncS
Application: ELISA
Application: ELISA, FC, IF, WB
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: WB, ELISA, Neut, FuncS
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, IHC, FC, IP, IF, Inhib
-3.jpg)
Application: Neut
-3.jpg)
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
