Anti-CDH1 (clone hSC10.17) Recombinant Antibody Coupled Liposome (VS-1024-FY171) (CAT#: VS-1024-FY171)
These specialized liposomes are designed to target CDH1, also known as E-cadherin, a protein commonly expressed on the surface of melanoma cells. By selectively binding to this molecule, the liposomes can enhance the precision of drug delivery, ensuring that the therapeutic agents are concentrated where they are most needed, thereby increasing their effectiveness. Furthermore, by interfering with cell adhesion signaling pathways, these liposomes may disrupt the tumor's ability to invade surrounding tissues, potentially leading to reduced metastasis and improved patient outcomes.
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28364/672_E7_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28364/672_E7_2_selected.jpg
Figure 2 ParaThyroid gland
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4812/158154_A_3_8_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4812/158154_A_3_8_val_selected.jpg
Figure 3 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_9_3.jpg
Figure 4 Liver
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_7_4.jpg
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_7_4.jpg
Figure 5 Kidney
(Bowman's capsule Staining: Medium Intensity: Moderate Quantity:>75% Collecting ducts Staining: High Intensity: Strong Quantity:>75% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_7_5.jpg
(Bowman's capsule Staining: Medium Intensity: Moderate Quantity:>75% Collecting ducts Staining: High Intensity: Strong Quantity:>75% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_7_5.jpg
Figure 1 Urinary bladder
(Urothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_5_5.jpg
(Urothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72856/157200_A_5_5.jpg
Figure 1 RNA cell line category: Cell line enhanced (BEWO, CACO-2, CAPAN-2, HaCaT, hTCEpi, MCF7, OE19, RT4, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000039068-CDH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000039068-CDH1
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- hSC10.17
- Antibody Type
- IgG1
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that has been specifically formulated to bind to CDH1, the gene encoding E-cadherin, which is crucial for maintaining cell-cell adhesion in epithelial tissues. The precision of this antibody allows researchers to investigate the role of E-cadherin in cancer progression and metastasis, particularly its function in tumor microenvironments. By focusing on CDH1, this tool can enhance our understanding of the molecular mechanisms that govern cellular integrity and communication within tissues.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CDH1
- Introduction
- This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
- Alternative Names
- Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO
- Full Name
- Cadherin 1
- Gene ID
- 999
- UniProt ID
- P12830
- Cellular Localization
- Cell junction, Cell membrane, Endosome, Golgi apparatus, Membrane
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1406CL | Anti-Human CDH1 Recombinant Antibody (SC10.19) | ELISA | |
| TAB-1407CL | Anti-Human CDH1 Recombinant Antibody (SC10.6) | ELISA | |
| TAB-1408CL | Anti-Human CDH1 Recombinant Antibody (SC10.178) | Cyt, FuncS | |
| TAB-1409CL | Anti-Human CDH1 Recombinant Antibody (SC10.15) | ELISA | |
| TAB-1410CL | Anti-Human CDH1 Recombinant Antibody (SC10.17) | Inhib |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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