Human Anti-CDH1 Recombinant Antibody (clone hSC10.17) (CAT#: HPAB-0467-WJ)
This product is a humanized antibody targeting human CDH1. This antibody recognizes both human and mouse CDH1. This antibody is generated using human VH3-48 (V), IGHD7-27 (D) and JH4 (J) for the heavy chain and human kappa light chain genes A17 and JK1.
Specific Inquiry
FuncS
Figure 1 demonstrates that humanized CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to cells expressing CD324, wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin and where the determined EC50 (e.g., half-maximal effective concentration) values are indicative of efficient cell killing.
FuncS
Figure 2 illustrate the in vivo efficacy of an exemplary antagonistic CD324 antibody in reducing the tumor size of two individual patient-derived NTX cells from pancreatic tumors.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Human CDH1
- Species Reactivity
- Human, Mouse
- Clone
- hSC10.17
- Applications
- ELISA, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry, Functional Assay, Cytotoxicity.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1406CL | Anti-Human CDH1 Recombinant Antibody (SC10.19) | ELISA | |
| TAB-1407CL | Anti-Human CDH1 Recombinant Antibody (SC10.6) | ELISA | |
| TAB-1408CL | Anti-Human CDH1 Recombinant Antibody (SC10.178) | Cyt, FuncS | |
| TAB-1409CL | Anti-Human CDH1 Recombinant Antibody (SC10.15) | ELISA | |
| TAB-1410CL | Anti-Human CDH1 Recombinant Antibody (SC10.17) | Inhib |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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